Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients
Abstract We investigated plasma phosphorylated tau217 (p-tau217) and p-tau181 efficacy in predicting positive amyloid positron emission tomography (PET) results and cognitive stage transitions. Plasma p-tau217 and p-tau181 were measured in participants who were cognitively unimpaired (CU, n = 121),...
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Nature Portfolio
2025-03-01
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| Online Access: | https://doi.org/10.1038/s41598-025-90232-8 |
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| author | Hyuk Sung Kwon Mina Hwang Seong-Ho Koh Seong Hye Choi Jae-Hong Lee Hyung-Ji Kim So-Hee Park Hyun-Hee Park Jee Hyang Jeong Myung Hoon Han Ji Young Kim |
| author_facet | Hyuk Sung Kwon Mina Hwang Seong-Ho Koh Seong Hye Choi Jae-Hong Lee Hyung-Ji Kim So-Hee Park Hyun-Hee Park Jee Hyang Jeong Myung Hoon Han Ji Young Kim |
| author_sort | Hyuk Sung Kwon |
| collection | DOAJ |
| description | Abstract We investigated plasma phosphorylated tau217 (p-tau217) and p-tau181 efficacy in predicting positive amyloid positron emission tomography (PET) results and cognitive stage transitions. Plasma p-tau217 and p-tau181 were measured in participants who were cognitively unimpaired (CU, n = 121), had mild cognitive impairment (n = 102), or dementia (n = 75) from two independent cohorts (Cohort 1: KBASE-V and Cohort 2: Asan) who underwent amyloid PET. In Cohort 1, plasma p-tau217 (area under the curve [AUC] = 0.938, P < 0.001) outperformed p-tau181 (AUC = 0.857, P < 0.001) in predicting amyloid PET positivity (P difference < 0.001). In Cohort 2, p-tau217 (AUC = 0.893, P < 0.001) and p-tau181 (AUC = 0.856, P < 0.001) showed comparably good discrimination for predicting amyloid PET positivity (P = 0.377). P-tau217 (AUC = 0.852, P < 0.001) and p-tau181 (AUC = 0.828, P < 0.001) demonstrated similarly good discriminations for predicting cognitive stage transition (P difference = 0.093). Plasma p-tau217 and p-tau181 predicted amyloid PET positivity and cognitive stage transitions well. Plasma p-tau217 might perform better, especially in the early stages. |
| format | Article |
| id | doaj-art-d6155a225ea34bb59e530d348b8ae0d8 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-d6155a225ea34bb59e530d348b8ae0d82025-08-20T02:59:19ZengNature PortfolioScientific Reports2045-23222025-03-011511910.1038/s41598-025-90232-8Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patientsHyuk Sung Kwon0Mina Hwang1Seong-Ho Koh2Seong Hye Choi3Jae-Hong Lee4Hyung-Ji Kim5So-Hee Park6Hyun-Hee Park7Jee Hyang Jeong8Myung Hoon Han9Ji Young Kim10Department of Neurology, Hanyang University Guri Hospital, Hanyang University College of MedicineDepartment of Neurology, Hanyang University Guri Hospital, Hanyang University College of MedicineDepartment of Neurology, Hanyang University Guri Hospital, Hanyang University College of MedicineDepartment of Neurology, Inha University College of MedicineDepartment of Neurology, University of Ulsan College of Medicine, Asan Medical CenterDepartment of Neurology, Uijeongbu Eulji Medical Center, Eulji UniversityDepartment of Neurology, Bobath Memorial HospitalDepartment of Neurology, Hanyang University Guri Hospital, Hanyang University College of MedicineDepartment of Neurology, Ewha Woman’s University School of MedicineDepartment of Neurosurgery, Hanyang University Guri Hospital, Hanyang University College of MedicineDepartment of Nuclear Medicine, Hanyang University Guri Hospital, Hanyang University College of MedicineAbstract We investigated plasma phosphorylated tau217 (p-tau217) and p-tau181 efficacy in predicting positive amyloid positron emission tomography (PET) results and cognitive stage transitions. Plasma p-tau217 and p-tau181 were measured in participants who were cognitively unimpaired (CU, n = 121), had mild cognitive impairment (n = 102), or dementia (n = 75) from two independent cohorts (Cohort 1: KBASE-V and Cohort 2: Asan) who underwent amyloid PET. In Cohort 1, plasma p-tau217 (area under the curve [AUC] = 0.938, P < 0.001) outperformed p-tau181 (AUC = 0.857, P < 0.001) in predicting amyloid PET positivity (P difference < 0.001). In Cohort 2, p-tau217 (AUC = 0.893, P < 0.001) and p-tau181 (AUC = 0.856, P < 0.001) showed comparably good discrimination for predicting amyloid PET positivity (P = 0.377). P-tau217 (AUC = 0.852, P < 0.001) and p-tau181 (AUC = 0.828, P < 0.001) demonstrated similarly good discriminations for predicting cognitive stage transition (P difference = 0.093). Plasma p-tau217 and p-tau181 predicted amyloid PET positivity and cognitive stage transitions well. Plasma p-tau217 might perform better, especially in the early stages.https://doi.org/10.1038/s41598-025-90232-8p-tau181p-tau217APOEAmyloid betaAmyloid positron emission tomographyAlzheimer’s disease |
| spellingShingle | Hyuk Sung Kwon Mina Hwang Seong-Ho Koh Seong Hye Choi Jae-Hong Lee Hyung-Ji Kim So-Hee Park Hyun-Hee Park Jee Hyang Jeong Myung Hoon Han Ji Young Kim Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients Scientific Reports p-tau181 p-tau217 APOE Amyloid beta Amyloid positron emission tomography Alzheimer’s disease |
| title | Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients |
| title_full | Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients |
| title_fullStr | Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients |
| title_full_unstemmed | Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients |
| title_short | Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patients |
| title_sort | comparison of plasma p tau217 and p tau181 in predicting amyloid positivity and prognosis among korean memory clinic patients |
| topic | p-tau181 p-tau217 APOE Amyloid beta Amyloid positron emission tomography Alzheimer’s disease |
| url | https://doi.org/10.1038/s41598-025-90232-8 |
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