Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific
Elimination of lymphatic filariasis (LF) in the Pacific Island Countries and Territories (PICT) has been defined as <0.1% circulating filarial antigen (CFA) prevalence in children born after the implementation of successful mass drug administrations (MDAs). This research assessed the feasibility...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/492023 |
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| author | Hayley Joseph Fuatai Maiava Take Naseri Fasihah Taleo Malakai ‘Ake Corinne Capuano Wayne Melrose |
| author_facet | Hayley Joseph Fuatai Maiava Take Naseri Fasihah Taleo Malakai ‘Ake Corinne Capuano Wayne Melrose |
| author_sort | Hayley Joseph |
| collection | DOAJ |
| description | Elimination of lymphatic filariasis (LF) in the Pacific Island Countries and Territories (PICT) has been defined as <0.1% circulating filarial antigen (CFA) prevalence in children born after the implementation of successful mass drug administrations (MDAs). This research assessed the feasibility of CFA and antibody testing in three countries; Tonga, Vanuatu, and Samoa. Transmission is interrupted in Vanuatu and Tonga as evidenced by no CFA positive children and a low antibody prevalence and titre. Transmission is ongoing in Samoa with microfilaraemic (Mf) and CFA positive children and a high antibody prevalence and titre. Furthermore, areas of transmission were identified with Mf positive adults, but no CFA positive children. These areas had a high antibody prevalence in children. In conclusion, CFA testing in children alone was not useful for identifying areas of residual endemicity in Samoa. Thus, it would be beneficial to include antibody serology in the PICT surveillance strategy. |
| format | Article |
| id | doaj-art-d6110dde6e924ae69a7cabf86fc6d8e3 |
| institution | OA Journals |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-d6110dde6e924ae69a7cabf86fc6d8e32025-08-20T02:19:38ZengWileyJournal of Tropical Medicine1687-96861687-96942011-01-01201110.1155/2011/492023492023Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South PacificHayley Joseph0Fuatai Maiava1Take Naseri2Fasihah Taleo3Malakai ‘Ake4Corinne Capuano5Wayne Melrose6Lymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, QLD 4811, AustraliaWorld Health Organization, Apia, SamoaMinistry of Health, Apia, SamoaVector Borne Disease Unit, Ministry of Health, Port Vila, VanuatuMinistry of Health, P.O. Box 59, Nuku'alofa, TongaWorld Health Organization, 50490 Kuala Lumpur, MalaysiaLymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, QLD 4811, AustraliaElimination of lymphatic filariasis (LF) in the Pacific Island Countries and Territories (PICT) has been defined as <0.1% circulating filarial antigen (CFA) prevalence in children born after the implementation of successful mass drug administrations (MDAs). This research assessed the feasibility of CFA and antibody testing in three countries; Tonga, Vanuatu, and Samoa. Transmission is interrupted in Vanuatu and Tonga as evidenced by no CFA positive children and a low antibody prevalence and titre. Transmission is ongoing in Samoa with microfilaraemic (Mf) and CFA positive children and a high antibody prevalence and titre. Furthermore, areas of transmission were identified with Mf positive adults, but no CFA positive children. These areas had a high antibody prevalence in children. In conclusion, CFA testing in children alone was not useful for identifying areas of residual endemicity in Samoa. Thus, it would be beneficial to include antibody serology in the PICT surveillance strategy.http://dx.doi.org/10.1155/2011/492023 |
| spellingShingle | Hayley Joseph Fuatai Maiava Take Naseri Fasihah Taleo Malakai ‘Ake Corinne Capuano Wayne Melrose Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific Journal of Tropical Medicine |
| title | Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific |
| title_full | Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific |
| title_fullStr | Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific |
| title_full_unstemmed | Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific |
| title_short | Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific |
| title_sort | application of the filariasis celisa antifilarial igg𝟒 antibody assay in surveillance in lymphatic filariasis elimination programmes in the south pacific |
| url | http://dx.doi.org/10.1155/2011/492023 |
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