From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody

From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody

IntroductionThe rapid evolution of SARS-CoV-2 Omicron variants highlights the urgent need for therapeutic strategies that can target viral evolution and leverage host immune recognition mechanisms. This study uses molecular dynamics (MD) simulations to analyze the immune evasion mechanisms of class...

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Bibliographic Details
Main Authors: Shuyuan Cao, Bo Sun, Feng Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
immune evasion
nanobody
computational pipeline
affinity maturation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1637955/full
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