Therapeutic effects of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content

Therapeutic effects of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content

IntroductionExtracellular vesicles (EVs) can potently inhibit inflammation yet there is a lack of understanding about the impact of donor characteristics on the efficacy of EVs. The goal of this study was to determine whether the sex and age of donor platelet-derived EVs (PEV) affected their ability...

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Main Authors: Danielle J. Beetler, Presley Giresi, Damian N. Di Florio, Jessica J. Fliess, Elizabeth J. McCabe, Molly M. Watkins, Vivian Xu, Matthew E. Auda, Katelyn A. Bruno, Emily R. Whelan, Stephen P. C. Kocsis, Brandy H. Edenfield, Sierra A. Walker, Logan P. Macomb, Kevin C. Keegan, Angita Jain, Andrea C. Morales-Lara, Isha Chekuri, Anneliese R. Hill, Houssam Farres, Joy Wolfram, Atta Behfar, Paul G. Stalboerger, Andre Terzic, Leslie T. Cooper, DeLisa Fairweather
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
coxsackievirus B3
innate immunity
complement
TLR4
sex differences
microRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1468969/full
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