Revisiting the role of cell death in cancer – promotion rather than inhibition
Cell death and its relations with cancer are subjects of significant misunderstanding within the scientific community, giving rise to numerous paradoxes. The prevailing perspective posits that oncogene activation diminishes cell death, resulting in accumulation of cells and the genesis of cancer. Th...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2025-01-01
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| Series: | Visualized Cancer Medicine |
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| Online Access: | https://vcm.edpsciences.org/articles/vcm/full_html/2025/01/vcm20240011/vcm20240011.html |
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| author | Wang Rui-An Li Zu-Guo |
| author_facet | Wang Rui-An Li Zu-Guo |
| author_sort | Wang Rui-An |
| collection | DOAJ |
| description | Cell death and its relations with cancer are subjects of significant misunderstanding within the scientific community, giving rise to numerous paradoxes. The prevailing perspective posits that oncogene activation diminishes cell death, resulting in accumulation of cells and the genesis of cancer. This article elucidates the difference between the pathological morphology of “necrosis” and the cellular demise concept of “necrosis” in cell biology, the influence of autophagy on cellular longevity, and the fundamentals of tumor suppression. It underscores the observation from pathology and literature that “resistance to apoptosis” is not an inherent trait of cancer. Rather than impeding, individual cell death actually fosters the progression of cancer as a whole. In fact, virtually all carcinogenic factors can trigger cellular apoptosis instead of extending cellular longevity. Contrary to conventional wisdom, genes promoting apoptosis exhibit carcinogenic properties, while those inhibiting apoptosis and cellular protective elements demonstrate anti-cancer effects. In essence, non-physiological cell death serves as a catalyst for tumorigenesis. |
| format | Article |
| id | doaj-art-d601baa53bab484581907a8dacd1810e |
| institution | OA Journals |
| issn | 2740-4218 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Visualized Cancer Medicine |
| spelling | doaj-art-d601baa53bab484581907a8dacd1810e2025-08-20T02:26:03ZengEDP SciencesVisualized Cancer Medicine2740-42182025-01-016710.1051/vcm/2025006vcm20240011Revisiting the role of cell death in cancer – promotion rather than inhibitionWang Rui-An0Li Zu-Guo1Department of Pathology, Shenzhen Hospital, Southern Medical UniversityDepartment of Pathology, Shenzhen Hospital, Southern Medical UniversityCell death and its relations with cancer are subjects of significant misunderstanding within the scientific community, giving rise to numerous paradoxes. The prevailing perspective posits that oncogene activation diminishes cell death, resulting in accumulation of cells and the genesis of cancer. This article elucidates the difference between the pathological morphology of “necrosis” and the cellular demise concept of “necrosis” in cell biology, the influence of autophagy on cellular longevity, and the fundamentals of tumor suppression. It underscores the observation from pathology and literature that “resistance to apoptosis” is not an inherent trait of cancer. Rather than impeding, individual cell death actually fosters the progression of cancer as a whole. In fact, virtually all carcinogenic factors can trigger cellular apoptosis instead of extending cellular longevity. Contrary to conventional wisdom, genes promoting apoptosis exhibit carcinogenic properties, while those inhibiting apoptosis and cellular protective elements demonstrate anti-cancer effects. In essence, non-physiological cell death serves as a catalyst for tumorigenesis.https://vcm.edpsciences.org/articles/vcm/full_html/2025/01/vcm20240011/vcm20240011.htmlcell deathapoptosisnecrosiscancertumorigenesisoncogenetumor suppressor |
| spellingShingle | Wang Rui-An Li Zu-Guo Revisiting the role of cell death in cancer – promotion rather than inhibition Visualized Cancer Medicine cell death apoptosis necrosis cancer tumorigenesis oncogene tumor suppressor |
| title | Revisiting the role of cell death in cancer – promotion rather than inhibition |
| title_full | Revisiting the role of cell death in cancer – promotion rather than inhibition |
| title_fullStr | Revisiting the role of cell death in cancer – promotion rather than inhibition |
| title_full_unstemmed | Revisiting the role of cell death in cancer – promotion rather than inhibition |
| title_short | Revisiting the role of cell death in cancer – promotion rather than inhibition |
| title_sort | revisiting the role of cell death in cancer promotion rather than inhibition |
| topic | cell death apoptosis necrosis cancer tumorigenesis oncogene tumor suppressor |
| url | https://vcm.edpsciences.org/articles/vcm/full_html/2025/01/vcm20240011/vcm20240011.html |
| work_keys_str_mv | AT wangruian revisitingtheroleofcelldeathincancerpromotionratherthaninhibition AT lizuguo revisitingtheroleofcelldeathincancerpromotionratherthaninhibition |