Effect of single dose dexamethasone (0.1 mg/kg) on white blood cell counts and serum glucose levels in healthy ewes
<b>Aim:</b> Aim of this research was to determine that effect of single dose dexamethasone (0.1 mg/kg, SC) on the white blood cell counts and serum glucose levels in healthy ewes. In addition, effects of dexamethasone on the other hemogram and serum biochemical values were evaluated.<...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1129 |
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| Summary: | <b>Aim:</b> Aim of this research was to determine that effect of
single dose dexamethasone (0.1 mg/kg, SC) on the white blood
cell counts and serum glucose levels in healthy ewes. In
addition, effects of dexamethasone on the other hemogram
and serum biochemical values were evaluated.<p>
<b>Materials and Methods:</b> Totally healthy 8 Akkaraman sheep
were received with 0.1 mg/kg (SC, single dose) dexamethasone.
Blood samples were taken before (0. hour, control) and
after treatments at 4, 8, 12, 24, 36, 48 and 72 hours. White
blood cell, red blood cell, platelet, hematocrit and hemoglobin
levels were measured by hemocell counter, whereas
serum glucose, lactate dehydrogenase, alkaline phosphatase,
total bilirubin, alanine aminotransferase, aspartate aminotransferase,
gamma glutamyltransferase, total protein,
albumin, blood urea nitrogen, creatinine, cholesterol, triglyceride,
high density lipoprotein and low density lipoprotein
levels were determined by auto-analyzer.<p>
<b>Results:</b> Dexamethasone increased (P<0.05) white blood
cell and glucose levels when compared to Control (0 hour),
and higher levels of these values were monitored during 48
hours. In addition, statistically significance changes were determined
in the total bilirubin, triglyceride and blood urea
nitrogen concentrations, but these results were within reference
range.<p>
<b>Conclusion:</b> It may be stated that dexamethasone increases
white blood cell count and glucose levels in sheep and its effect
may be determined during 2-3 days after treatments. |
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| ISSN: | 1309-6958 2146-1953 |