CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Abstract Ferroptosis is emerging as a novel mechanism for understanding renal tubular injury in diabetic nephropathy (DN). The mitochondria‐associated endoplasmic reticulum membrane (MAM) plays a crucial role in the regulation of numerous cellular processes, including mitochondrial dysfunction and e...

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Main Authors: Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
canopy FGF signaling regulator 2 (CNPY2)
diabetic nephropathy
endoplasmic reticulum (ER) stress
ferroptosis
mitochondria‐associated endoplasmic reticulum membrane (MAM)
Online Access:https://doi.org/10.1002/advs.202416441
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