Tailored Therapy in Lung Cancer
Historically, all non-small cell lung cancers were essentially grouped together and considered to be a single disease. However, it is now recognized that non-small cell lung cancer actually comprises a genetically diverse group of tumours. This, in turn, affords a new opportunity for the development...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/506383 |
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| _version_ | 1832553973632991232 |
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| author | George Rakovich Lise Tremblay |
| author_facet | George Rakovich Lise Tremblay |
| author_sort | George Rakovich |
| collection | DOAJ |
| description | Historically, all non-small cell lung cancers were essentially grouped together and considered to be a single disease. However, it is now recognized that non-small cell lung cancer actually comprises a genetically diverse group of tumours. This, in turn, affords a new opportunity for the development of effective treatments tailored to individual tumours and patients. Advances in molecular biology have made possible the development of drugs against specific molecular targets on cancer cells, most notably the tyrosine kinase inhibitors. The relevant literature and current practice guidelines are discussed. In addition, other related areas of active investigation, including tumour vaccines and pharmacogenetics, are briefly reviewed. |
| format | Article |
| id | doaj-art-d5fbb51b076442f1b13b107a1ff5cd43 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-d5fbb51b076442f1b13b107a1ff5cd432025-02-03T05:52:50ZengWileyCanadian Respiratory Journal1198-22412013-01-0120536736810.1155/2013/506383Tailored Therapy in Lung CancerGeorge Rakovich0Lise Tremblay1Division of Thoracic Surgery, Hôpital Maisonneuve Rosemont, University of Montreal, Montreal, CanadaDivision of Respirology, Institut Universitaire de Cardiologie et de Pneumologie de Québec – Laval University, Quebec City, Quebec, CanadaHistorically, all non-small cell lung cancers were essentially grouped together and considered to be a single disease. However, it is now recognized that non-small cell lung cancer actually comprises a genetically diverse group of tumours. This, in turn, affords a new opportunity for the development of effective treatments tailored to individual tumours and patients. Advances in molecular biology have made possible the development of drugs against specific molecular targets on cancer cells, most notably the tyrosine kinase inhibitors. The relevant literature and current practice guidelines are discussed. In addition, other related areas of active investigation, including tumour vaccines and pharmacogenetics, are briefly reviewed.http://dx.doi.org/10.1155/2013/506383 |
| spellingShingle | George Rakovich Lise Tremblay Tailored Therapy in Lung Cancer Canadian Respiratory Journal |
| title | Tailored Therapy in Lung Cancer |
| title_full | Tailored Therapy in Lung Cancer |
| title_fullStr | Tailored Therapy in Lung Cancer |
| title_full_unstemmed | Tailored Therapy in Lung Cancer |
| title_short | Tailored Therapy in Lung Cancer |
| title_sort | tailored therapy in lung cancer |
| url | http://dx.doi.org/10.1155/2013/506383 |
| work_keys_str_mv | AT georgerakovich tailoredtherapyinlungcancer AT lisetremblay tailoredtherapyinlungcancer |