Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study.
The recent discovery of hepcidin, the key iron regulatory hormone, has changed our view of iron metabolism, which in turn is long known to be linked with insulin resistant states, including type 2 diabetes mellitus and the Metabolic Syndrome (MetS). Serum ferritin levels are often elevated in MetS (...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048250&type=printable |
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| author | Nicola Martinelli Michela Traglia Natascia Campostrini Ginevra Biino Michela Corbella Cinzia Sala Fabiana Busti Corrado Masciullo Daniele Manna Sara Previtali Annalisa Castagna Giorgio Pistis Oliviero Olivieri Daniela Toniolo Clara Camaschella Domenico Girelli |
| author_facet | Nicola Martinelli Michela Traglia Natascia Campostrini Ginevra Biino Michela Corbella Cinzia Sala Fabiana Busti Corrado Masciullo Daniele Manna Sara Previtali Annalisa Castagna Giorgio Pistis Oliviero Olivieri Daniela Toniolo Clara Camaschella Domenico Girelli |
| author_sort | Nicola Martinelli |
| collection | DOAJ |
| description | The recent discovery of hepcidin, the key iron regulatory hormone, has changed our view of iron metabolism, which in turn is long known to be linked with insulin resistant states, including type 2 diabetes mellitus and the Metabolic Syndrome (MetS). Serum ferritin levels are often elevated in MetS (Dysmetabolic hyperferritinemia--DHF), and are sometimes associated with a true mild-to-moderate hepatic iron overload (dysmetabolic iron overload syndrome--DIOS). However, the pathophysiological link between iron and MetS remains unclear. This study was aimed to investigate, for the first time, the relationship between MetS and hepcidin at population level. We measured serum hepcidin levels by Mass Spectrometry in 1,391 subjects from the Val Borbera population, and evaluated their relationship with classical MetS features. Hepcidin levels increased significantly and linearly with increasing number of MetS features, paralleling the trend of serum ferritin. In multivariate models adjusted for relevant variables including age, C-Reactive Protein, and the HFE C282Y mutation, ferritin was the only significant independent predictor of hepcidin in males, while in females MetS was also independently associated with hepcidin. Overall, these data indicate that the fundamental iron regulatory feedback is preserved in MetS, i.e. that hepcidin tends to progressively increase in response to the increase of iron stores. Due to recently discovered pleiotropic effects of hepcidin, this may worsen insulin resistance and contribute to the cardiovascular complications of MetS. |
| format | Article |
| id | doaj-art-d5f4cede18944a958f6ea808a11acf42 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d5f4cede18944a958f6ea808a11acf422025-08-20T03:09:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4825010.1371/journal.pone.0048250Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study.Nicola MartinelliMichela TragliaNatascia CampostriniGinevra BiinoMichela CorbellaCinzia SalaFabiana BustiCorrado MasciulloDaniele MannaSara PrevitaliAnnalisa CastagnaGiorgio PistisOliviero OlivieriDaniela TonioloClara CamaschellaDomenico GirelliThe recent discovery of hepcidin, the key iron regulatory hormone, has changed our view of iron metabolism, which in turn is long known to be linked with insulin resistant states, including type 2 diabetes mellitus and the Metabolic Syndrome (MetS). Serum ferritin levels are often elevated in MetS (Dysmetabolic hyperferritinemia--DHF), and are sometimes associated with a true mild-to-moderate hepatic iron overload (dysmetabolic iron overload syndrome--DIOS). However, the pathophysiological link between iron and MetS remains unclear. This study was aimed to investigate, for the first time, the relationship between MetS and hepcidin at population level. We measured serum hepcidin levels by Mass Spectrometry in 1,391 subjects from the Val Borbera population, and evaluated their relationship with classical MetS features. Hepcidin levels increased significantly and linearly with increasing number of MetS features, paralleling the trend of serum ferritin. In multivariate models adjusted for relevant variables including age, C-Reactive Protein, and the HFE C282Y mutation, ferritin was the only significant independent predictor of hepcidin in males, while in females MetS was also independently associated with hepcidin. Overall, these data indicate that the fundamental iron regulatory feedback is preserved in MetS, i.e. that hepcidin tends to progressively increase in response to the increase of iron stores. Due to recently discovered pleiotropic effects of hepcidin, this may worsen insulin resistance and contribute to the cardiovascular complications of MetS.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048250&type=printable |
| spellingShingle | Nicola Martinelli Michela Traglia Natascia Campostrini Ginevra Biino Michela Corbella Cinzia Sala Fabiana Busti Corrado Masciullo Daniele Manna Sara Previtali Annalisa Castagna Giorgio Pistis Oliviero Olivieri Daniela Toniolo Clara Camaschella Domenico Girelli Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. PLoS ONE |
| title | Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. |
| title_full | Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. |
| title_fullStr | Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. |
| title_full_unstemmed | Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. |
| title_short | Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. |
| title_sort | increased serum hepcidin levels in subjects with the metabolic syndrome a population study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048250&type=printable |
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