Physiological mechanisms of absorption in the intestine. Basic groups of substances
The aim of the publication. To discuss physiological mechanisms of absorption in a gastro-intestinal tract.Original positions. Mechanisms of transport of nutrients and other substances across mucosa of the gut are analyzed. Mechanisms of coupled transport of glucose, aminoacids and sodium – models o...
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| Main Author: | |
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| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2009-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1685 |
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| Summary: | The aim of the publication. To discuss physiological mechanisms of absorption in a gastro-intestinal tract.Original positions. Mechanisms of transport of nutrients and other substances across mucosa of the gut are analyzed. Mechanisms of coupled transport of glucose, aminoacids and sodium – models of common transporter (that seems to be improbable) and common canal are considered. Two-channel model of sodium and glucose transport looks the most probable.Conclusion. The comprehension of mechanisms Na+-dependent absorption of glucose and aminoacids allows to prove scientifically, first, application of a well known drug for relief of secretory diarrhea, second, forms a basis for development of pharmaceuticals, capable to be absorbed efficiently through Na+- dependent transporters for aminoacids, third, promotes search of strategies increasing rate of absorption of medicines. Registration of spectrums of Na+-dependent absorption of nutrients in the small intestine is a key to comprehension of malabsorption role in development of several diseases. |
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| ISSN: | 1382-4376 2658-6673 |