Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice
Objectives. The creation of new herbal medicines for their use in dentistry is relevant. The purpose of this work is to study the acute toxicity of the anticaries dental gel (ACDG3) developed by us based on Origanum vulgare. Results. In case of studying the safety of anticaries dental gel “ACDG3” in...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2023/6691694 |
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| author | Karakoz Badekova Gayane Atazhanova Irina Losseva Aigul Medeshova Ailazzat Aitkenova Anar Brazhanova |
| author_facet | Karakoz Badekova Gayane Atazhanova Irina Losseva Aigul Medeshova Ailazzat Aitkenova Anar Brazhanova |
| author_sort | Karakoz Badekova |
| collection | DOAJ |
| description | Objectives. The creation of new herbal medicines for their use in dentistry is relevant. The purpose of this work is to study the acute toxicity of the anticaries dental gel (ACDG3) developed by us based on Origanum vulgare. Results. In case of studying the safety of anticaries dental gel “ACDG3” in animals, that with a single dose of up to 2000 mg/kg, the absence of pathological changes in the behavior of animals was noted. Biochemical studies indicate that the studied doses of dental gel did not lead to significant deviations in the blood parameters of mice and deviations fluctuated within the reference values. According to the results of a morphometric study conducted 15 days after the administration of the drug, no deviations were found. The histological evaluation of organs showed little change in the cardiac architecture in animals treated with ACDG3 at doses of 1000 mg/kg and 2000 mg/kg. On the other hand, no significant changes in the cardiac function were observed in all treated mice. Conclusion. As follows from the results obtained, in case of determining acute toxicity, the studied anticaries gel, ACDG3, showed low toxicity. For mice, LD50 was 2000 mg/kg intragastrically. So, according to the generally accepted classification of the toxicity of substances, ACDG3 can be attributed to the class of low-toxic substances (IV class of toxicity, LD50 > 5000 mg/kg, intragastric administration), that is, to practically nontoxic compounds. |
| format | Article |
| id | doaj-art-d5efcc0805ed426ab476affc7f3099f6 |
| institution | Kabale University |
| issn | 1687-8205 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-d5efcc0805ed426ab476affc7f3099f62025-02-03T01:29:49ZengWileyJournal of Toxicology1687-82052023-01-01202310.1155/2023/6691694Acute Toxicity of Dental Gel Based on Origanum vulgare in MiceKarakoz Badekova0Gayane Atazhanova1Irina Losseva2Aigul Medeshova3Ailazzat Aitkenova4Anar Brazhanova5Institute of Life ScienceInstitute of Life ScienceInstitute of Life ScienceInstitute of Life ScienceInstitute of Life ScienceInstitute of Life ScienceObjectives. The creation of new herbal medicines for their use in dentistry is relevant. The purpose of this work is to study the acute toxicity of the anticaries dental gel (ACDG3) developed by us based on Origanum vulgare. Results. In case of studying the safety of anticaries dental gel “ACDG3” in animals, that with a single dose of up to 2000 mg/kg, the absence of pathological changes in the behavior of animals was noted. Biochemical studies indicate that the studied doses of dental gel did not lead to significant deviations in the blood parameters of mice and deviations fluctuated within the reference values. According to the results of a morphometric study conducted 15 days after the administration of the drug, no deviations were found. The histological evaluation of organs showed little change in the cardiac architecture in animals treated with ACDG3 at doses of 1000 mg/kg and 2000 mg/kg. On the other hand, no significant changes in the cardiac function were observed in all treated mice. Conclusion. As follows from the results obtained, in case of determining acute toxicity, the studied anticaries gel, ACDG3, showed low toxicity. For mice, LD50 was 2000 mg/kg intragastrically. So, according to the generally accepted classification of the toxicity of substances, ACDG3 can be attributed to the class of low-toxic substances (IV class of toxicity, LD50 > 5000 mg/kg, intragastric administration), that is, to practically nontoxic compounds.http://dx.doi.org/10.1155/2023/6691694 |
| spellingShingle | Karakoz Badekova Gayane Atazhanova Irina Losseva Aigul Medeshova Ailazzat Aitkenova Anar Brazhanova Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice Journal of Toxicology |
| title | Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice |
| title_full | Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice |
| title_fullStr | Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice |
| title_full_unstemmed | Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice |
| title_short | Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice |
| title_sort | acute toxicity of dental gel based on origanum vulgare in mice |
| url | http://dx.doi.org/10.1155/2023/6691694 |
| work_keys_str_mv | AT karakozbadekova acutetoxicityofdentalgelbasedonoriganumvulgareinmice AT gayaneatazhanova acutetoxicityofdentalgelbasedonoriganumvulgareinmice AT irinalosseva acutetoxicityofdentalgelbasedonoriganumvulgareinmice AT aigulmedeshova acutetoxicityofdentalgelbasedonoriganumvulgareinmice AT ailazzataitkenova acutetoxicityofdentalgelbasedonoriganumvulgareinmice AT anarbrazhanova acutetoxicityofdentalgelbasedonoriganumvulgareinmice |