Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

Over 90% of the U.S. adult population suffers from tooth structure loss due to caries. Most of the mineralized tooth structure is composed of dentin, a material produced and mineralized by ectomesenchyme derived cells known as odontoblasts. Clinicians, scientists, and the general public share the de...

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Bibliographic Details
Main Authors: Sesha Hanson-Drury, Anjali P. Patni, Deborah L. Lee, Ammar Alghadeer, Yan Ting Zhao, Devon Duron Ehnes, Vivian N. Vo, Sydney Y. Kim, Druthi Jithendra, Ashish Phal, Natasha I. Edman, Thomas Schlichthaerle, David Baker, Jessica E. Young, Julie Mathieu, Hannele Ruohola-Baker
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Dental Medicine
Subjects:
odontoblast
single cell RNA sequencing
enamel knot
cell signaling
de novo designed mini protein binders
human tooth
Online Access:https://www.frontiersin.org/articles/10.3389/fdmed.2023.1209503/full
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