Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma

Sporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report...

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Bibliographic Details
Main Authors: Kaushik Mandal, Damilola Ashorobi, Alice Lee, Huijuan Liao, Salini C. Kumar, David S. Rosenthal
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Endocrinology
Online Access:http://dx.doi.org/10.1155/2021/8479193
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Summary:Sporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report an additional case of a patient with multiple myeloma and an IgG paraproteinemia who had such a spurious elevation of total T3 complicating her levothyroxine management of hypothyroidism. In addition, we alert clinicians that differences in performance characteristics between various manufacturers’ test platforms may also cause spurious reports.
ISSN:2090-6501
2090-651X