Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactions

Photomechanochemistry, i.e., the merger of light energy and mechanical forces, is emerging as a new trend in organic synthesis, enabling unique reactivities of fleeting excited states under solvent-minimized conditions. Despite its transformative potential, the field faces significant technological...

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Main Authors: Francesco Mele, Ana M. Constantin, Andrea Porcheddu, Raimondo Maggi, Giovanni Maestri, Nicola Della Ca’, Luca Capaldo
Format: Article
Language:English
Published: Beilstein-Institut 2025-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.21.33
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author Francesco Mele
Ana M. Constantin
Andrea Porcheddu
Raimondo Maggi
Giovanni Maestri
Nicola Della Ca’
Luca Capaldo
author_facet Francesco Mele
Ana M. Constantin
Andrea Porcheddu
Raimondo Maggi
Giovanni Maestri
Nicola Della Ca’
Luca Capaldo
author_sort Francesco Mele
collection DOAJ
description Photomechanochemistry, i.e., the merger of light energy and mechanical forces, is emerging as a new trend in organic synthesis, enabling unique reactivities of fleeting excited states under solvent-minimized conditions. Despite its transformative potential, the field faces significant technological challenges that must be addressed to unlock its full capabilities. In this Perspective, we analyze selected examples to showcase the available technologies to combine light and mechanical forces, including manual grinding, vortex and shaker mixing, rod milling, and ball milling. By examining the advantages and limitations of each approach, we aim to provide an overview of the current state of synthetic photomechanochemistry to identify opportunities for future advancements in this rapidly evolving area of research.
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publisher Beilstein-Institut
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series Beilstein Journal of Organic Chemistry
spelling doaj-art-d5e04ed615cc4f17ba285d8c1f583e262025-08-20T03:15:50ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972025-03-0121145847210.3762/bjoc.21.331860-5397-21-33Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactionsFrancesco Mele0Ana M. Constantin1Andrea Porcheddu2Raimondo Maggi3Giovanni Maestri4Nicola Della Ca’5Luca Capaldo6SynCat Lab, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy SynCat Lab, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS554 bivio per Sestu, 09042-Monserrato (CA), Italy SynCat Lab, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy CIRCC (Interuniversity Consortium Chemical Reactivity and Catalysis), via Celso Ulpiani 27, 70126 Bari, Italy SynCat Lab, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy SynCat Lab, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy Photomechanochemistry, i.e., the merger of light energy and mechanical forces, is emerging as a new trend in organic synthesis, enabling unique reactivities of fleeting excited states under solvent-minimized conditions. Despite its transformative potential, the field faces significant technological challenges that must be addressed to unlock its full capabilities. In this Perspective, we analyze selected examples to showcase the available technologies to combine light and mechanical forces, including manual grinding, vortex and shaker mixing, rod milling, and ball milling. By examining the advantages and limitations of each approach, we aim to provide an overview of the current state of synthetic photomechanochemistry to identify opportunities for future advancements in this rapidly evolving area of research.https://doi.org/10.3762/bjoc.21.33light-mediated synthesismechanochemistryphotomechanochemistry
spellingShingle Francesco Mele
Ana M. Constantin
Andrea Porcheddu
Raimondo Maggi
Giovanni Maestri
Nicola Della Ca’
Luca Capaldo
Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactions
Beilstein Journal of Organic Chemistry
light-mediated synthesis
mechanochemistry
photomechanochemistry
title Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactions
title_full Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactions
title_fullStr Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactions
title_full_unstemmed Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactions
title_short Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactions
title_sort photomechanochemistry harnessing mechanical forces to enhance photochemical reactions
topic light-mediated synthesis
mechanochemistry
photomechanochemistry
url https://doi.org/10.3762/bjoc.21.33
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AT raimondomaggi photomechanochemistryharnessingmechanicalforcestoenhancephotochemicalreactions
AT giovannimaestri photomechanochemistryharnessingmechanicalforcestoenhancephotochemicalreactions
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