Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis
Abstract S-methyl thioesters have proven to be useful intermediates in many biosynthetic reactions and their occurrence in bioactive molecules further enhance their appeal. Shortcomings in several reported synthetic protocols have led us to disclose herewith a mild, room temperature ex situ protocol...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-97728-3 |
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| author | Manisha A. Patel Vandana Sharma Rupali Chavan Juhi Pal Santosh J. Gharpure Anant R. Kapdi |
| author_facet | Manisha A. Patel Vandana Sharma Rupali Chavan Juhi Pal Santosh J. Gharpure Anant R. Kapdi |
| author_sort | Manisha A. Patel |
| collection | DOAJ |
| description | Abstract S-methyl thioesters have proven to be useful intermediates in many biosynthetic reactions and their occurrence in bioactive molecules further enhance their appeal. Shortcomings in several reported synthetic protocols have led us to disclose herewith a mild, room temperature ex situ protocol that provides access to a large number of thioesters (aryl, heteroaryl, alkyl, amino acids). Late-stage functionalization strategies were also performed on commercial pharmaceutical drugs (containing carboxylic acid functionality) while further in situ conversion to valuable compounds has also been achieved. |
| format | Article |
| id | doaj-art-d5dfb71c2cb849999ca262d5fea71451 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d5dfb71c2cb849999ca262d5fea714512025-08-20T02:03:30ZengNature PortfolioScientific Reports2045-23222025-05-0115111310.1038/s41598-025-97728-3Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesisManisha A. Patel0Vandana Sharma1Rupali Chavan2Juhi Pal3Santosh J. Gharpure4Anant R. Kapdi5Department of Chemistry, Institute of Chemical TechnologyDepartment of Chemistry, Institute of Chemical TechnologyDepartment of Chemistry, Indian Institute of Technology BombayDepartment of Chemistry, Indian Institute of Technology BombayDepartment of Chemistry, Indian Institute of Technology BombayDepartment of Chemistry, Institute of Chemical TechnologyAbstract S-methyl thioesters have proven to be useful intermediates in many biosynthetic reactions and their occurrence in bioactive molecules further enhance their appeal. Shortcomings in several reported synthetic protocols have led us to disclose herewith a mild, room temperature ex situ protocol that provides access to a large number of thioesters (aryl, heteroaryl, alkyl, amino acids). Late-stage functionalization strategies were also performed on commercial pharmaceutical drugs (containing carboxylic acid functionality) while further in situ conversion to valuable compounds has also been achieved.https://doi.org/10.1038/s41598-025-97728-3 |
| spellingShingle | Manisha A. Patel Vandana Sharma Rupali Chavan Juhi Pal Santosh J. Gharpure Anant R. Kapdi Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis Scientific Reports |
| title | Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis |
| title_full | Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis |
| title_fullStr | Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis |
| title_full_unstemmed | Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis |
| title_short | Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis |
| title_sort | room temperature metal free cdi promoted ex situ protocol for s methyl thioester synthesis |
| url | https://doi.org/10.1038/s41598-025-97728-3 |
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