Use of the Adaptive Behaviour Dementia Questionnaire in a Down Syndrome Specialty Clinic
Objective: To study the use of a dementia screening tool in our clinic cohort of adults with Down syndrome. Study Design: A retrospective chart review of patients with Down syndrome was conducted to follow the u...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2025-01-01
|
| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/24/1/10.31083/JIN25713 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586605634781184 |
|---|---|
| author | Nicolas M. Oreskovic Ayesha Harisinghani Caroline Bregman Clorinda Cottrell Margaret Pulsifer Brian G. Skotko Amy Torres Alexa Gozdiff Spognardi Stephanie L. Santoro |
| author_facet | Nicolas M. Oreskovic Ayesha Harisinghani Caroline Bregman Clorinda Cottrell Margaret Pulsifer Brian G. Skotko Amy Torres Alexa Gozdiff Spognardi Stephanie L. Santoro |
| author_sort | Nicolas M. Oreskovic |
| collection | DOAJ |
| description | Objective: To study the use of a dementia screening tool in our clinic cohort of adults with Down syndrome. Study Design: A retrospective chart review of patients with Down syndrome was conducted to follow the use of the Adaptive Behaviour Dementia Questionnaire (ABDQ) in a dementia screening protocol. The ABDQ results for patients aged 40 years and older at a Down syndrome specialty clinic program were assessed. Based on caregiver feedback, an ABDQ with modified instructions was piloted and the impact assessed. Results: As part of our clinic’s initiative to implement a new clinical protocol to screen for dementia, the ABDQ was completed by 47 caregivers of adults with Down syndrome, aged 39 years and above, from December, 2021 to April, 2023. Based on clinical impressions at the same timepoint, the ABDQ had a sensitivity of 0%, specificity of 97.4%, positive predictive value of 0%, and negative predictive value of 80.4%. Nine patients were deemed to have mild cognitive impairment and/or dementia by clinical impressions, but they did not identify as positive on the ABDQ. The Down syndrome clinic team modified the ABDQ in an effort to provide clearer language and increased sensitivity. The modified ABDQ showed a sensitivity of 0%, specificity of 93.8%, positive predictive value of 0% and negative predictive value of 75%. Conclusion: Neither the original ABDQ nor a modified version adequately identified patients with cognitive impairment and/or dementia within the Down syndrome clinical program. The inability to replicate findings from the initial ABDQ validation may be due to differences in setting and format. |
| format | Article |
| id | doaj-art-d5dc56f8075a4dd09969204b2c6954f1 |
| institution | Kabale University |
| issn | 0219-6352 1757-448X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-d5dc56f8075a4dd09969204b2c6954f12025-01-25T07:38:07ZengIMR PressJournal of Integrative Neuroscience0219-63521757-448X2025-01-012412571310.31083/JIN25713S0219-6352(24)00869-6Use of the Adaptive Behaviour Dementia Questionnaire in a Down Syndrome Specialty ClinicNicolas M. Oreskovic0Ayesha Harisinghani1Caroline Bregman2Clorinda Cottrell3Margaret Pulsifer4Brian G. Skotko5Amy Torres6Alexa Gozdiff Spognardi7Stephanie L. Santoro8Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USADown Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USADown Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USADown Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USADown Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USADown Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USADown Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USADown Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USADown Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USAObjective: To study the use of a dementia screening tool in our clinic cohort of adults with Down syndrome. Study Design: A retrospective chart review of patients with Down syndrome was conducted to follow the use of the Adaptive Behaviour Dementia Questionnaire (ABDQ) in a dementia screening protocol. The ABDQ results for patients aged 40 years and older at a Down syndrome specialty clinic program were assessed. Based on caregiver feedback, an ABDQ with modified instructions was piloted and the impact assessed. Results: As part of our clinic’s initiative to implement a new clinical protocol to screen for dementia, the ABDQ was completed by 47 caregivers of adults with Down syndrome, aged 39 years and above, from December, 2021 to April, 2023. Based on clinical impressions at the same timepoint, the ABDQ had a sensitivity of 0%, specificity of 97.4%, positive predictive value of 0%, and negative predictive value of 80.4%. Nine patients were deemed to have mild cognitive impairment and/or dementia by clinical impressions, but they did not identify as positive on the ABDQ. The Down syndrome clinic team modified the ABDQ in an effort to provide clearer language and increased sensitivity. The modified ABDQ showed a sensitivity of 0%, specificity of 93.8%, positive predictive value of 0% and negative predictive value of 75%. Conclusion: Neither the original ABDQ nor a modified version adequately identified patients with cognitive impairment and/or dementia within the Down syndrome clinical program. The inability to replicate findings from the initial ABDQ validation may be due to differences in setting and format.https://www.imrpress.com/journal/JIN/24/1/10.31083/JIN25713dementiaalzheimer’s diseasedown syndromeclinical screening |
| spellingShingle | Nicolas M. Oreskovic Ayesha Harisinghani Caroline Bregman Clorinda Cottrell Margaret Pulsifer Brian G. Skotko Amy Torres Alexa Gozdiff Spognardi Stephanie L. Santoro Use of the Adaptive Behaviour Dementia Questionnaire in a Down Syndrome Specialty Clinic Journal of Integrative Neuroscience dementia alzheimer’s disease down syndrome clinical screening |
| title | Use of the Adaptive Behaviour Dementia Questionnaire in a Down Syndrome Specialty Clinic |
| title_full | Use of the Adaptive Behaviour Dementia Questionnaire in a Down Syndrome Specialty Clinic |
| title_fullStr | Use of the Adaptive Behaviour Dementia Questionnaire in a Down Syndrome Specialty Clinic |
| title_full_unstemmed | Use of the Adaptive Behaviour Dementia Questionnaire in a Down Syndrome Specialty Clinic |
| title_short | Use of the Adaptive Behaviour Dementia Questionnaire in a Down Syndrome Specialty Clinic |
| title_sort | use of the adaptive behaviour dementia questionnaire in a down syndrome specialty clinic |
| topic | dementia alzheimer’s disease down syndrome clinical screening |
| url | https://www.imrpress.com/journal/JIN/24/1/10.31083/JIN25713 |
| work_keys_str_mv | AT nicolasmoreskovic useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic AT ayeshaharisinghani useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic AT carolinebregman useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic AT clorindacottrell useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic AT margaretpulsifer useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic AT briangskotko useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic AT amytorres useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic AT alexagozdiffspognardi useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic AT stephanielsantoro useoftheadaptivebehaviourdementiaquestionnaireinadownsyndromespecialtyclinic |