Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care
Neoadjuvant (presurgical) anti-programmed cell death protein-1 (PD-1)-based immunotherapy as a new approach to cancer treatment has been developing on an accelerated trajectory since the seminal clinical trial results from studies in lung cancer and melanoma were published in 2018. Groundbreaking re...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/13/1/e010833.full |
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| _version_ | 1823858152726069248 |
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| author | Drew M Pardoll Suzanne L Topalian |
| author_facet | Drew M Pardoll Suzanne L Topalian |
| author_sort | Drew M Pardoll |
| collection | DOAJ |
| description | Neoadjuvant (presurgical) anti-programmed cell death protein-1 (PD-1)-based immunotherapy as a new approach to cancer treatment has been developing on an accelerated trajectory since the seminal clinical trial results from studies in lung cancer and melanoma were published in 2018. Groundbreaking regulatory approvals in triple-negative breast cancer, non-small cell lung cancer and melanoma will certainly be followed by additional approvals in other disease indications, as clinical and basic research are burgeoning globally in hundreds of clinical trials across dozens of cancer types. As this field is evolving, it is addressing gaps in our understanding of biological mechanisms underlying PD-1 pathway blockade and their synergy with other antineoplastic drugs, probing mechanisms of response and resistance to neoadjuvant immunotherapy, optimizing efficacious clinical strategies, and analyzing commonalities and differences across cancer types. Knowledge gained thus far provides a firm foundation from which to launch the next phase of translational research in this expanding arena of biomedical investigation. |
| format | Article |
| id | doaj-art-d5dbc5e4d07b4a528da1f5f31ee27a89 |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-d5dbc5e4d07b4a528da1f5f31ee27a892025-02-11T14:05:12ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262025-01-0113110.1136/jitc-2024-010833Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of careDrew M Pardoll0Suzanne L Topalian11Bloomberg~Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA3 The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USANeoadjuvant (presurgical) anti-programmed cell death protein-1 (PD-1)-based immunotherapy as a new approach to cancer treatment has been developing on an accelerated trajectory since the seminal clinical trial results from studies in lung cancer and melanoma were published in 2018. Groundbreaking regulatory approvals in triple-negative breast cancer, non-small cell lung cancer and melanoma will certainly be followed by additional approvals in other disease indications, as clinical and basic research are burgeoning globally in hundreds of clinical trials across dozens of cancer types. As this field is evolving, it is addressing gaps in our understanding of biological mechanisms underlying PD-1 pathway blockade and their synergy with other antineoplastic drugs, probing mechanisms of response and resistance to neoadjuvant immunotherapy, optimizing efficacious clinical strategies, and analyzing commonalities and differences across cancer types. Knowledge gained thus far provides a firm foundation from which to launch the next phase of translational research in this expanding arena of biomedical investigation.https://jitc.bmj.com/content/13/1/e010833.full |
| spellingShingle | Drew M Pardoll Suzanne L Topalian Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care Journal for ImmunoTherapy of Cancer |
| title | Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care |
| title_full | Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care |
| title_fullStr | Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care |
| title_full_unstemmed | Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care |
| title_short | Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care |
| title_sort | neoadjuvant anti pd 1 based immunotherapy evolving a new standard of care |
| url | https://jitc.bmj.com/content/13/1/e010833.full |
| work_keys_str_mv | AT drewmpardoll neoadjuvantantipd1basedimmunotherapyevolvinganewstandardofcare AT suzanneltopalian neoadjuvantantipd1basedimmunotherapyevolvinganewstandardofcare |