Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemotherapy alone: a randomized controlled trial

Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemotherapy alone: a randomized controlled trial

Abstract Background Based on current guidelines, surgical treatment of hepatic oligometastases in patients with pancreatic ductal adenocarcinoma (PDAC) is not primarily recommended. Systematic chemotherapy is the therapy of choice for these patients. The relevance of subsequent surgical resection af...

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Main Authors: Michael Ghadimi, Uwe Pelzer, Marc G. Besselink, Jens Siveke, Ralph Telgmann, Rickmer Braren, Hanneke Wilmink, Marie Crede, Alexander Koenig, Ute Koenig, Sven Thorsten Liffers, Kai Antweiler, Bas Uijterwijk, Hanna Seppanen, Arno Nordin, Pauli Puolakkainen, Olav F. Dajani, Knut Jørgen Labori, Mia Johansson, Svein Olav Bratlie, Tim Friede, Peter Jo
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
Oligometastasis
Pancreatic ductal carcinoma (PDAC)
Oligometastatic pancreatic cancer
Liver metastasis
Multimodal treatment
Chemotherapy
Online Access:https://doi.org/10.1186/s12885-025-13573-7
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