Predictors of renal outcome in ANCA-assosiated glomerulonephritis
Backgraund/Aim. Primary anti-neutrophil cytoplasmatic antibody (ANCA)-associated vasculitis are chronic multisystemic autoimmune diseases which include microscopic polyangitis (MPA), granulomatosis with polyangitis (WG), eosinophilic granulomatosis with polyangitis (EPGA; churg-strauss syndrome – CS...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2021-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900135L.pdf |
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| author | Ljubičić Bojana Azaševac Tijana Popović Milica Živković Siniša Božić Dušan Ćelić Dejan |
| author_facet | Ljubičić Bojana Azaševac Tijana Popović Milica Živković Siniša Božić Dušan Ćelić Dejan |
| author_sort | Ljubičić Bojana |
| collection | DOAJ |
| description | Backgraund/Aim. Primary anti-neutrophil cytoplasmatic antibody (ANCA)-associated vasculitis are chronic multisystemic autoimmune diseases which include microscopic polyangitis (MPA), granulomatosis with polyangitis (WG), eosinophilic granulomatosis with polyangitis (EPGA; churg-strauss syndrome – CSS), and also a localized forms of ill-ness. In our research, we studied clinical and serological parameters in patients, in order to find out which of them would be the best predictor of renal outcome in ANCA-associated vasculitis. Methods. Data from 42 patients with diagnose of MPA (9), WG (17), EPGA (0), CSS (0), and al-so idiopathic rapidly progressive glomerulonephritis (ROEB) without immune deposits (renal-limited vasculitis – 16) were analyzed. Cockroft formula was used for calculating the glomerular filtration in the moment of presenting the illness, and also after five year follow-up period. Other factors that were analyzed are: gender, age, type of ANCA antibodies, type of infections, stage of chronic kidney dis-ease, need for heamodialysis and mortality. Results. Of a total of 42 patients, 17 (40.48%) were male. The average age of the patients at the time of diagnosis was 57.8 (± 10.44) years. Seventeen patients (40.48%) had a diagnosis of WG, 9 (21.43%) MPA, and 16 (38.09%) iRPGN. The presence of positive anti-proteinase (anti-PR3) antibodies was confirmed i n 1 8 patients, a nd a nti-MPO antibodies in 17 patients. Three patients had both subtypes of ANCA antibodies (anti-PR3 and anti-MPO). Initially, 12 patients required heamodialysis treatment. Twenty nine patients had a complete and 13 patients had partial remission. Out of the total number of patients, 8 patients (19.04%) developed the terminal renal failure stage, and ended up on a chronic dialysis program. During a five-year follow-up period, 12 patients (28.57%) resulted in death. The age of the patient proved to be statistically significant predictor of glomerular filtration rate (GFR) at the moment of presentation of the disease (p = 0.011). GFR t = 0 was statistically significant (p = 0.000) for the evaluation of kidney function outcomes in ANCA-associated glomerulonephritis. Conclusion. Kidney function in the moment of illness presentation, determined by GFR t = 0, is the most important significant factor for predicting renal outcome in ANCA-associated vasculitis, and also the mortality in these patients. |
| format | Article |
| id | doaj-art-d5d75ae4644f496493948cd8e34d375c |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-d5d75ae4644f496493948cd8e34d375c2025-08-20T02:04:09ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202021-01-0178776977410.2298/VSP190903135L0042-84501900135LPredictors of renal outcome in ANCA-assosiated glomerulonephritisLjubičić Bojana0Azaševac Tijana1Popović Milica2Živković Siniša3Božić Dušan4Ćelić Dejan5Clinical Centre of Vojvodina, Emergency Centre, Department of Emergency Internal Medicine, Novi Sad, SerbiaClinical Centre of Vojvodina, Emergency Centre, Clinic for Nephrology and Clinical Immunology, Novi Sad, SerbiaClinical Centre of Vojvodina, Emergency Centre, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department of Internal Medicine, Novi Sad, Serbia Clinical Centre of Vojvodina, Emergency Centre, Clinic for Nephrology and Clinical Immunology, Novi Sad, SerbiaClinical Centre of Vojvodina, Emergency Centre, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department of Internal Medicine, Novi Sad, Serbia Clinical Centre of Vojvodina, Emergency Centre, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department of Internal Medicine, Novi Sad, Serbia Backgraund/Aim. Primary anti-neutrophil cytoplasmatic antibody (ANCA)-associated vasculitis are chronic multisystemic autoimmune diseases which include microscopic polyangitis (MPA), granulomatosis with polyangitis (WG), eosinophilic granulomatosis with polyangitis (EPGA; churg-strauss syndrome – CSS), and also a localized forms of ill-ness. In our research, we studied clinical and serological parameters in patients, in order to find out which of them would be the best predictor of renal outcome in ANCA-associated vasculitis. Methods. Data from 42 patients with diagnose of MPA (9), WG (17), EPGA (0), CSS (0), and al-so idiopathic rapidly progressive glomerulonephritis (ROEB) without immune deposits (renal-limited vasculitis – 16) were analyzed. Cockroft formula was used for calculating the glomerular filtration in the moment of presenting the illness, and also after five year follow-up period. Other factors that were analyzed are: gender, age, type of ANCA antibodies, type of infections, stage of chronic kidney dis-ease, need for heamodialysis and mortality. Results. Of a total of 42 patients, 17 (40.48%) were male. The average age of the patients at the time of diagnosis was 57.8 (± 10.44) years. Seventeen patients (40.48%) had a diagnosis of WG, 9 (21.43%) MPA, and 16 (38.09%) iRPGN. The presence of positive anti-proteinase (anti-PR3) antibodies was confirmed i n 1 8 patients, a nd a nti-MPO antibodies in 17 patients. Three patients had both subtypes of ANCA antibodies (anti-PR3 and anti-MPO). Initially, 12 patients required heamodialysis treatment. Twenty nine patients had a complete and 13 patients had partial remission. Out of the total number of patients, 8 patients (19.04%) developed the terminal renal failure stage, and ended up on a chronic dialysis program. During a five-year follow-up period, 12 patients (28.57%) resulted in death. The age of the patient proved to be statistically significant predictor of glomerular filtration rate (GFR) at the moment of presentation of the disease (p = 0.011). GFR t = 0 was statistically significant (p = 0.000) for the evaluation of kidney function outcomes in ANCA-associated glomerulonephritis. Conclusion. Kidney function in the moment of illness presentation, determined by GFR t = 0, is the most important significant factor for predicting renal outcome in ANCA-associated vasculitis, and also the mortality in these patients.http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900135L.pdfglomerulonephritisantibodies, antineutrophil cytoplasmicglomerular filtration ratemortality |
| spellingShingle | Ljubičić Bojana Azaševac Tijana Popović Milica Živković Siniša Božić Dušan Ćelić Dejan Predictors of renal outcome in ANCA-assosiated glomerulonephritis Vojnosanitetski Pregled glomerulonephritis antibodies, antineutrophil cytoplasmic glomerular filtration rate mortality |
| title | Predictors of renal outcome in ANCA-assosiated glomerulonephritis |
| title_full | Predictors of renal outcome in ANCA-assosiated glomerulonephritis |
| title_fullStr | Predictors of renal outcome in ANCA-assosiated glomerulonephritis |
| title_full_unstemmed | Predictors of renal outcome in ANCA-assosiated glomerulonephritis |
| title_short | Predictors of renal outcome in ANCA-assosiated glomerulonephritis |
| title_sort | predictors of renal outcome in anca assosiated glomerulonephritis |
| topic | glomerulonephritis antibodies, antineutrophil cytoplasmic glomerular filtration rate mortality |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900135L.pdf |
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