A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis
BackgroundDespite having negative lymph node (N0) status, thyroid cancer (TC) patients can still experience distant metastasis (DM), which significantly impacts their survival. This study aimed to investigate the prognostic factors for DM in TC patients (N0) and develop a predictive nomogram model f...
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| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1523785/full |
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| author | Xiaoqing Yu Qin Deng Xin Gao Lingyun He Daixing Hu Lu Yang |
| author_facet | Xiaoqing Yu Qin Deng Xin Gao Lingyun He Daixing Hu Lu Yang |
| author_sort | Xiaoqing Yu |
| collection | DOAJ |
| description | BackgroundDespite having negative lymph node (N0) status, thyroid cancer (TC) patients can still experience distant metastasis (DM), which significantly impacts their survival. This study aimed to investigate the prognostic factors for DM in TC patients (N0) and develop a predictive nomogram model for analyzing the prognosis of TC N0 patients with DM.MethodsData collected from the Surveillance, Epidemiology, and End Results (SEER) database for 18,504 TC patients (N0) between 2004 and 2015 were analyzed. Univariate and multivariate analyses were used to identify independent prognostic factors for DM in TC N0. These independent factors were used to build a nomogram model to predict overall survival (OS) at 1, 3, and 5 years for TC patients (N0) with DM.Results and conclusionThis study examined the clinicopathological features associated with the risk and prognosis of DM in TC patients (N0), and successfully established and validated a nomogram capable of predicting OS in individual patients with DM. The nomogram is highly useful for the timely identification of TC patients (N0) at high risk of DM by physicians, enabling individualized survival evaluations and treatment for TC patients with DM (N0). |
| format | Article |
| id | doaj-art-d5d6493c3a49465d8c8b7abaec2df86a |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-d5d6493c3a49465d8c8b7abaec2df86a2025-08-20T03:01:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15237851523785A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasisXiaoqing Yu0Qin Deng1Xin Gao2Lingyun He3Daixing Hu4Lu Yang5Department of Breast and Thyroid Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Breast and Thyroid Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaHepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaScientific Research and Education Section, Chongqing Health Center for Women and Children, Chongqing, ChinaDepartment of Breast and Thyroid Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Breast and Thyroid Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackgroundDespite having negative lymph node (N0) status, thyroid cancer (TC) patients can still experience distant metastasis (DM), which significantly impacts their survival. This study aimed to investigate the prognostic factors for DM in TC patients (N0) and develop a predictive nomogram model for analyzing the prognosis of TC N0 patients with DM.MethodsData collected from the Surveillance, Epidemiology, and End Results (SEER) database for 18,504 TC patients (N0) between 2004 and 2015 were analyzed. Univariate and multivariate analyses were used to identify independent prognostic factors for DM in TC N0. These independent factors were used to build a nomogram model to predict overall survival (OS) at 1, 3, and 5 years for TC patients (N0) with DM.Results and conclusionThis study examined the clinicopathological features associated with the risk and prognosis of DM in TC patients (N0), and successfully established and validated a nomogram capable of predicting OS in individual patients with DM. The nomogram is highly useful for the timely identification of TC patients (N0) at high risk of DM by physicians, enabling individualized survival evaluations and treatment for TC patients with DM (N0).https://www.frontiersin.org/articles/10.3389/fendo.2025.1523785/fullthyroid cancerdistant metastasisrisk factornomogramoverall survival |
| spellingShingle | Xiaoqing Yu Qin Deng Xin Gao Lingyun He Daixing Hu Lu Yang A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis Frontiers in Endocrinology thyroid cancer distant metastasis risk factor nomogram overall survival |
| title | A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis |
| title_full | A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis |
| title_fullStr | A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis |
| title_full_unstemmed | A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis |
| title_short | A prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis |
| title_sort | prognostic nomogram for distant metastasis in thyroid cancer patients without lymph node metastasis |
| topic | thyroid cancer distant metastasis risk factor nomogram overall survival |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1523785/full |
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