Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East
Background. The clinical pattern and genetic background of juvenile idiopathic chronic pancreatitis (ICP) are yet unclear. Methods. A retrospective study of 73 Chinese juvenile ICP patients was performed, and genetic tests were carried out to detect relevant mutations using direct sequencing techniq...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/7548753 |
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| author | Muyun Liu Tian Xia Di Zhang Lianghao Hu Zhuan Liao Chang Sun Zhaoshen Li |
| author_facet | Muyun Liu Tian Xia Di Zhang Lianghao Hu Zhuan Liao Chang Sun Zhaoshen Li |
| author_sort | Muyun Liu |
| collection | DOAJ |
| description | Background. The clinical pattern and genetic background of juvenile idiopathic chronic pancreatitis (ICP) are yet unclear. Methods. A retrospective study of 73 Chinese juvenile ICP patients was performed, and genetic tests were carried out to detect relevant mutations using direct sequencing technique and high-resolution melting technique. Subjects without pancreatitis served as controls. Results. The SPINK1 c.194+2T>C variant was present in 56.16% and 42.00% of juvenile and adult ICP patients, respectively (p=0.020), but was not present in any of the control subjects. Thirty-four (46.58%) of the 73 juvenile ICP patients were male, and a significantly higher ratio of male patients in the adult group was identified (46.58% versus 64.00%, p=0.022). Although most of the juvenile patients presented with abdominal pain (70/73, 95.89%), the patterns of pain attack are significantly different in patients with or without SPINK1 c.194+2T>C mutation. Patients carrying the mutation are more likely to present with recurrent acute pancreatitis (70.70%). Conclusions. The main symptom of pediatric ICP was abdominal pain. SPINK1 c.194+2T>C mutation had a higher occurrence in juvenile ICP patients than in adult group and typically presented with recurrent acute pancreatitis. There may be unidentified factors that lead to a greater incidence rate of ICP in adult male population. |
| format | Article |
| id | doaj-art-d5d4d0a50d134fcfa5fa452c5a569a0b |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d5d4d0a50d134fcfa5fa452c5a569a0b2025-08-20T02:19:38ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/75487537548753Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the EastMuyun Liu0Tian Xia1Di Zhang2Lianghao Hu3Zhuan Liao4Chang Sun5Zhaoshen Li6Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, ChinaBackground. The clinical pattern and genetic background of juvenile idiopathic chronic pancreatitis (ICP) are yet unclear. Methods. A retrospective study of 73 Chinese juvenile ICP patients was performed, and genetic tests were carried out to detect relevant mutations using direct sequencing technique and high-resolution melting technique. Subjects without pancreatitis served as controls. Results. The SPINK1 c.194+2T>C variant was present in 56.16% and 42.00% of juvenile and adult ICP patients, respectively (p=0.020), but was not present in any of the control subjects. Thirty-four (46.58%) of the 73 juvenile ICP patients were male, and a significantly higher ratio of male patients in the adult group was identified (46.58% versus 64.00%, p=0.022). Although most of the juvenile patients presented with abdominal pain (70/73, 95.89%), the patterns of pain attack are significantly different in patients with or without SPINK1 c.194+2T>C mutation. Patients carrying the mutation are more likely to present with recurrent acute pancreatitis (70.70%). Conclusions. The main symptom of pediatric ICP was abdominal pain. SPINK1 c.194+2T>C mutation had a higher occurrence in juvenile ICP patients than in adult group and typically presented with recurrent acute pancreatitis. There may be unidentified factors that lead to a greater incidence rate of ICP in adult male population.http://dx.doi.org/10.1155/2017/7548753 |
| spellingShingle | Muyun Liu Tian Xia Di Zhang Lianghao Hu Zhuan Liao Chang Sun Zhaoshen Li Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East Gastroenterology Research and Practice |
| title | Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East |
| title_full | Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East |
| title_fullStr | Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East |
| title_full_unstemmed | Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East |
| title_short | Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East |
| title_sort | genetic background and clinical characters of pediatric chronic pancreatitis data and implications from the east |
| url | http://dx.doi.org/10.1155/2017/7548753 |
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