Inflammatory Response to Cobalt-Chromium Alloys Fabricated With Different Techniques
Objectives: To explore the in vitro cytokine expression of human peripheral blood mononuclear cells exposed to cobalt-chromium alloys, manufactured with different techniques, in comparison with commercially pure titanium grade 4 and titanium alloy grade 23. Material and Methods: Peripheral blood...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Lithuanian University of Health Sciences, Faculty of Odontology
2021-12-01
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| Series: | eJournal of Oral Maxillofacial Research |
| Subjects: | |
| Online Access: | https://www.ejomr.org/JOMR/archives/2021/4/e3/v12n4e3ht.htm |
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| Summary: | Objectives: To explore the in vitro cytokine expression of human peripheral blood mononuclear cells exposed to cobalt-chromium alloys, manufactured with different techniques, in comparison with commercially pure titanium grade 4 and titanium alloy grade 23.
Material and Methods: Peripheral blood mononuclear cells (PBMC) were collected from 10 healthy blood donors and exposed to machine-ground coin-shaped: (a) cobalt-chromium (Co-Cr) specimens (n = 5) manufactured by four techniques, i.e. cast, milled, laser melted and presintered milled; (b) commercially pure titanium grade 4; and (c) titanium alloy grade 23. The cells were cultured for 4, 24 and 72 hours followed by investigations of pro- and anti-inflammatory cytokine release using Bio-Plex Pro™.
Results: In general, the PBMC produced significantly more cytokines when exposed to the cast and presintered milled Co-Cr materials compared to laser melted, milled Co-Cr and titanium materials.
Conclusions: Within the limitation of the present study, it may be suggested that cast and presintered milled cobalt-chromium alloys provoke a stronger inflammatory response compared to milled and laser melted cobalt-chromium alloys and titanium materials. |
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| ISSN: | 2029-283X |