Can mutation abundance assess the biological behavior of BRAF V600E-positive papillary thyroid carcinoma?

Can mutation abundance assess the biological behavior of BRAF V600E-positive papillary thyroid carcinoma?

Abstract Background BRAF V600E mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAF V600E mutation status and abundance and the biological behavior of PTC is unclear. Thus, this study investigated whether BRAF V600E mutation stat...

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Main Authors: Yeqin Ni, Ping Song, Xiangfeng Lin, Jingjing Shi, Qian Shi, Yuanhui Li, Siyu Zhu, Tianhan Zhou, Yanping Xun, Shirong Zhang, Xingchang Ren, Kaining Lu, Fan Wu, Wei Wang, Pan Zhao, Rongjing Zhou, Wenhua Zhang, Dandan Li, Jiaoping Zhang, Chuanghua Chen, Linlin Mao, Li Zhou, Gang Pan, You Peng, Yunxian Yu, Yuying Chen, Rong Ni, Guhan Luo, Yu Zhang, Jugao Fang, Haitao Zheng, Dingcun Luo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Thyroid cancer
BRAF V600E mutation abundance
Risk stratification
Machine learning
Clinical decision
Online Access:https://doi.org/10.1186/s12967-025-06493-4
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