Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China
Echovirus 11 (E11) has gained attention owing to its association with severe neonatal infections. From 2018 to 2023, a surge in severe neonatal cases and fatalities linked to a novel variant of genotype D5 was documented in China, France, and Italy. However, the prevention and control of E11 variant...
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2361814 |
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| author | Liu Ying Sun Qiang Xiao Jinbo Ren Binzhi Zhao Hua Shi Yong Zhou Shuaifeng Hong Mei Zhou Kangping Cun Jianping Zeng Yunting Chen Jianhua Ge Qiong Ju Yu Lu Huanhuan Li Jichen Cong Ruyi Yang Tingting Wang Rui Zong Yanjun Sun Tiantian Yu Liheng Wang Xiaoyi Zhu Shuangli Yan Dongmei Ji Tianjiao Yang Qian Zhu Zhen Zhang Yong |
| author_facet | Liu Ying Sun Qiang Xiao Jinbo Ren Binzhi Zhao Hua Shi Yong Zhou Shuaifeng Hong Mei Zhou Kangping Cun Jianping Zeng Yunting Chen Jianhua Ge Qiong Ju Yu Lu Huanhuan Li Jichen Cong Ruyi Yang Tingting Wang Rui Zong Yanjun Sun Tiantian Yu Liheng Wang Xiaoyi Zhu Shuangli Yan Dongmei Ji Tianjiao Yang Qian Zhu Zhen Zhang Yong |
| author_sort | Liu Ying |
| collection | DOAJ |
| description | Echovirus 11 (E11) has gained attention owing to its association with severe neonatal infections. From 2018 to 2023, a surge in severe neonatal cases and fatalities linked to a novel variant of genotype D5 was documented in China, France, and Italy. However, the prevention and control of E11 variants have been hampered by limited background data on the virus circulation and genetic variance. Therefore, the present study investigated the circulating dynamics of E11 and the genetic variation and molecular evolution of genotype D5 through the collection of strains from the national acute flaccid paralysis (AFP) and hand, foot, and mouth disease (HFMD) surveillance system in China during 2000–2022 and genetic sequences published in the GenBank database. The results of this study revealed a prevalent dynamic of E11 circulation, with D5 being the predominant genotype worldwide. Further phylogenetic analysis of genotype D5 indicated that it could be subdivided into three important geographic clusters (D5-CHN1: 2014–2019, D5-CHN2: 2016–2022, and D5-EUR: 2022–2023). Additionally, variant-specific (144) amino acid mutation sites and positive-selection pressure sites (132, 262) were identified in the VP1 region. Cluster-specific recombination patterns were also identified, with CVB5, E6, and CVB4 as the major recombinant viruses. These findings provide a preliminary landscape of E11 circulation worldwide and basic scientific data for further study of the pathogenicity of E11 variants. |
| format | Article |
| id | doaj-art-d5cbd69d67c84b8bb6dffda8eb311167 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Emerging Microbes and Infections |
| spelling | doaj-art-d5cbd69d67c84b8bb6dffda8eb3111672025-08-20T02:37:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2361814Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in ChinaLiu Ying0Sun Qiang1Xiao Jinbo2Ren Binzhi3Zhao Hua4Shi Yong5Zhou Shuaifeng6Hong Mei7Zhou Kangping8Cun Jianping9Zeng Yunting10Chen Jianhua11Ge Qiong12Ju Yu13Lu Huanhuan14Li Jichen15Cong Ruyi16Yang Tingting17Wang Rui18Zong Yanjun19Sun Tiantian20Yu Liheng21Wang Xiaoyi22Zhu Shuangli23Yan Dongmei24Ji Tianjiao25Yang Qian26Zhu Zhen27Zhang Yong28National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaPathogen Detection Laboratory, Shanxi Provincial Center for Disease Control and Prevention, Shanxi, People’s Republic of ChinaPathogen Detection Laboratory, Chongqing Provincial Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaPathogen Detection Laboratory, Jiangxi Provincial Center for Disease Control and Prevention, Jiangxi, People’s Republic of ChinaPathogen Detection Laboratory, Hunan Provincial Center for Disease Control and Prevention, Hunan, People’s Republic of ChinaPathogen Detection Laboratory, Xizang Provincial Center for Disease Control and Prevention, Xizang, People’s Republic of ChinaPathogen Detection Laboratory, Hubei Provincial Center for Disease Control and Prevention, Hubei, People’s Republic of ChinaPathogen Detection Laboratory, Yunnan Provincial Center for Disease Control and Prevention, Yunnan, People’s Republic of ChinaPathogen Detection Laboratory, Hainan Provincial Center for Disease Control and Prevention, Hainan, People’s Republic of ChinaPathogen Detection Laboratory, Gansu Provincial Center for Disease Control and Prevention, Gansu, People’s Republic of ChinaPathogen Detection Laboratory, Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, People’s Republic of ChinaPathogen Detection Laboratory, Guangxi Provincial Center for Disease Control and Prevention, Guangxi, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaEchovirus 11 (E11) has gained attention owing to its association with severe neonatal infections. From 2018 to 2023, a surge in severe neonatal cases and fatalities linked to a novel variant of genotype D5 was documented in China, France, and Italy. However, the prevention and control of E11 variants have been hampered by limited background data on the virus circulation and genetic variance. Therefore, the present study investigated the circulating dynamics of E11 and the genetic variation and molecular evolution of genotype D5 through the collection of strains from the national acute flaccid paralysis (AFP) and hand, foot, and mouth disease (HFMD) surveillance system in China during 2000–2022 and genetic sequences published in the GenBank database. The results of this study revealed a prevalent dynamic of E11 circulation, with D5 being the predominant genotype worldwide. Further phylogenetic analysis of genotype D5 indicated that it could be subdivided into three important geographic clusters (D5-CHN1: 2014–2019, D5-CHN2: 2016–2022, and D5-EUR: 2022–2023). Additionally, variant-specific (144) amino acid mutation sites and positive-selection pressure sites (132, 262) were identified in the VP1 region. Cluster-specific recombination patterns were also identified, with CVB5, E6, and CVB4 as the major recombinant viruses. These findings provide a preliminary landscape of E11 circulation worldwide and basic scientific data for further study of the pathogenicity of E11 variants.https://www.tandfonline.com/doi/10.1080/22221751.2024.2361814EnterovirusEchovirus 11molecular epidemiologyvariantsvirus evolutionvirus transmission |
| spellingShingle | Liu Ying Sun Qiang Xiao Jinbo Ren Binzhi Zhao Hua Shi Yong Zhou Shuaifeng Hong Mei Zhou Kangping Cun Jianping Zeng Yunting Chen Jianhua Ge Qiong Ju Yu Lu Huanhuan Li Jichen Cong Ruyi Yang Tingting Wang Rui Zong Yanjun Sun Tiantian Yu Liheng Wang Xiaoyi Zhu Shuangli Yan Dongmei Ji Tianjiao Yang Qian Zhu Zhen Zhang Yong Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China Emerging Microbes and Infections Enterovirus Echovirus 11 molecular epidemiology variants virus evolution virus transmission |
| title | Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China |
| title_full | Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China |
| title_fullStr | Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China |
| title_full_unstemmed | Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China |
| title_short | Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China |
| title_sort | genetic variation and evolutionary characteristics of echovirus 11 new variant within genotype d5 associated with neonatal death found in china |
| topic | Enterovirus Echovirus 11 molecular epidemiology variants virus evolution virus transmission |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2361814 |
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