Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when exces...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8746114 |
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| _version_ | 1832555207666434048 |
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| author | Xinyuan Zhang Kaiyue Wang Ling Zhu Qiyun Wang |
| author_facet | Xinyuan Zhang Kaiyue Wang Ling Zhu Qiyun Wang |
| author_sort | Xinyuan Zhang |
| collection | DOAJ |
| description | Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR. |
| format | Article |
| id | doaj-art-d5ca6af705484aa69bc910ac555ba320 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d5ca6af705484aa69bc910ac555ba3202025-02-03T05:49:26ZengWileyJournal of Diabetes Research2314-67532021-01-01202110.1155/2021/87461148746114Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic RetinopathyXinyuan Zhang0Kaiyue Wang1Ling Zhu2Qiyun Wang3Beijing Institute of OphthalmologyBeijing Institute of OphthalmologySave Sight InstituteBeijing Institute of OphthalmologyCholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR.http://dx.doi.org/10.1155/2021/8746114 |
| spellingShingle | Xinyuan Zhang Kaiyue Wang Ling Zhu Qiyun Wang Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy Journal of Diabetes Research |
| title | Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy |
| title_full | Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy |
| title_fullStr | Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy |
| title_full_unstemmed | Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy |
| title_short | Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy |
| title_sort | reverse cholesterol transport pathway and cholesterol efflux in diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2021/8746114 |
| work_keys_str_mv | AT xinyuanzhang reversecholesteroltransportpathwayandcholesteroleffluxindiabeticretinopathy AT kaiyuewang reversecholesteroltransportpathwayandcholesteroleffluxindiabeticretinopathy AT lingzhu reversecholesteroltransportpathwayandcholesteroleffluxindiabeticretinopathy AT qiyunwang reversecholesteroltransportpathwayandcholesteroleffluxindiabeticretinopathy |