Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients
Introduction: The distribution of both malaria and schistosomiasis exhibits a large geographical overlap in tropical environments, particularly in sub-Saharan Africa. This part of the world currently harbours more than 85% of the estimated global burden of these diseases. Studies showed that artemi...
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The Journal of Infection in Developing Countries
2013-06-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/2658 |
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| author | Solomon M Abay Mulugeta Tilahun Nigus Fikrie Abiy Habtewold |
| author_facet | Solomon M Abay Mulugeta Tilahun Nigus Fikrie Abiy Habtewold |
| author_sort | Solomon M Abay |
| collection | DOAJ |
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Introduction: The distribution of both malaria and schistosomiasis exhibits a large geographical overlap in tropical environments, particularly in sub-Saharan Africa. This part of the world currently harbours more than 85% of the estimated global burden of these diseases. Studies showed that artemisinin derivatives used for the treatment of malaria also have an antischistosomal effect. This study aimed to investigate the extent of malaria-schistosomiasis co-infection and the antischistosomal effect of artemether-lumefantrine when administered to treat falciparum malaria in Kemise, Northeast Ethiopia.
Methodology: Stool samples were collected from 152 microscopically confirmed malaria patients and diagnosed for schistosomiasis using the Kato-Katz technique before treatment. The schistosomiasis cure rate and egg reduction were determined in co-infected patients, who were treated with artemether-lumefantrine,.
Results: Twenty-eight out of 152 malaria patients were co-infected (18.4%, n = 152) with schistosomiasis. All 28 co-infected patients were found stool-negative for Schistosoma mansoni eggs four weeks after treatment. The extent of co-infection was associated with age, sex and educational level. Cure rate and egg reduction rate following the treatment of artemether-lumefantrine were 100%.
Conclusion: The co-infection rate was associated with patient characteristics. Artemether-lumefantrine was effective against S. mansoni in co-infected patient. Multicenter and randomized trials, however, are needed for a better understanding of the efficacy of artemether-lumefantrine against schistosome infection with ranges of intensity.
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| format | Article |
| id | doaj-art-d5c57963c0cf4934b71d4e036afde7d2 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2013-06-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-d5c57963c0cf4934b71d4e036afde7d22025-08-20T02:57:45ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802013-06-0170610.3855/jidc.2658Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patientsSolomon M Abay0Mulugeta Tilahun1Nigus Fikrie2Abiy Habtewold3School of Medicine, Addis Ababa University, Addis Ababa, EthiopiaSchool of Medicine, Addis Ababa University, EthiopiaSchool of Medicine, Addis Ababa University, EthiopiaSchool of Medicine, Addis Ababa University, Addis Ababa, Ethiopia Introduction: The distribution of both malaria and schistosomiasis exhibits a large geographical overlap in tropical environments, particularly in sub-Saharan Africa. This part of the world currently harbours more than 85% of the estimated global burden of these diseases. Studies showed that artemisinin derivatives used for the treatment of malaria also have an antischistosomal effect. This study aimed to investigate the extent of malaria-schistosomiasis co-infection and the antischistosomal effect of artemether-lumefantrine when administered to treat falciparum malaria in Kemise, Northeast Ethiopia. Methodology: Stool samples were collected from 152 microscopically confirmed malaria patients and diagnosed for schistosomiasis using the Kato-Katz technique before treatment. The schistosomiasis cure rate and egg reduction were determined in co-infected patients, who were treated with artemether-lumefantrine,. Results: Twenty-eight out of 152 malaria patients were co-infected (18.4%, n = 152) with schistosomiasis. All 28 co-infected patients were found stool-negative for Schistosoma mansoni eggs four weeks after treatment. The extent of co-infection was associated with age, sex and educational level. Cure rate and egg reduction rate following the treatment of artemether-lumefantrine were 100%. Conclusion: The co-infection rate was associated with patient characteristics. Artemether-lumefantrine was effective against S. mansoni in co-infected patient. Multicenter and randomized trials, however, are needed for a better understanding of the efficacy of artemether-lumefantrine against schistosome infection with ranges of intensity. https://jidc.org/index.php/journal/article/view/2658schistosomiasis and malaria co-infectionartemether-lumefantrineS. mansoniP. falciparumEthiopia |
| spellingShingle | Solomon M Abay Mulugeta Tilahun Nigus Fikrie Abiy Habtewold Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients Journal of Infection in Developing Countries schistosomiasis and malaria co-infection artemether-lumefantrine S. mansoni P. falciparum Ethiopia |
| title | Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients |
| title_full | Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients |
| title_fullStr | Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients |
| title_full_unstemmed | Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients |
| title_short | Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients |
| title_sort | plasmodium falciparum and schistosoma mansoni coinfection and the side benefit of artemether lumefantrine in malaria patients |
| topic | schistosomiasis and malaria co-infection artemether-lumefantrine S. mansoni P. falciparum Ethiopia |
| url | https://jidc.org/index.php/journal/article/view/2658 |
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