Dyslipidemia, body mass index, and blood glucose levels in patients with meibomian gland dysfunction
Background Systemic dyslipidemia, obesity, and elevated blood sugars may theoretically affect the meibomian lipid composition and therefore, can cause meibomian gland dysfunction (MGD). Objective This study aimed to evaluate the association of serum lipid levels, body mass index (BMI), and se...
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Delta Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/djop/fulltext/2024/25020/dyslipidemia,_body_mass_index,_and_blood_glucose.1.aspx |
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| author | Meenu Babber Reena Sharma Brijesh Singh Vandana Yadav Ravi Ranjan |
| author_facet | Meenu Babber Reena Sharma Brijesh Singh Vandana Yadav Ravi Ranjan |
| author_sort | Meenu Babber |
| collection | DOAJ |
| description | Background
Systemic dyslipidemia, obesity, and elevated blood sugars may theoretically affect the meibomian lipid composition and therefore, can cause meibomian gland dysfunction (MGD).
Objective
This study aimed to evaluate the association of serum lipid levels, body mass index (BMI), and serum blood glucose (BG) levels in patients with MGD compared with healthy controls.
Patients and methods
This is a comparative observational case-control study that enrolled 40 MGD patients (cases) and 40 controls. One eye of each participant was included in the study. After a detailed history, ocular examination was done by slit lamp biomicroscopy to grade/stage the MGD. The BMI, serum fasting total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, and BG levels were measured.
Results
The mean age of the cases was 46.75±10.93 years compared with 45.55±10.62 years in controls (P=0.620). Patients with MGD showed significantly higher serum fasting cholesterol (188.62±62.24 mg/dl),;Deg;BM;Deg;I (24.45±1.75 kg/m2), and fasting BG (110.35±32.30 mg/dl) compared with the controls (159.60±20.19 mg/dl, 23.45±1.35 kg/m2, and 98.43±27.69 mg/dl, respectively, P=0.022, 0.005, and 0.030, respectively). With increasing severity of MGD, the fasting serum cholesterol increased significantly from 136.73±24.88 mg/dl in grade 1 to 285.20±85.99 mg/dl in grade 4 (P<0.001) and the fasting serum LDL levels increased from 72.64±20.33 mg/dl in grade 1 to 202.60±95.66 mg/dl in grade 4 (P<0.001). In addition, the fasting serum triglycerides increased significantly as the severity of MGD increased from grade I (96.00±22.56 mg/dl) to grade III (227.09±83.44 mg/dl), (P<0.001). However, The fasting HDL and BG values did not increase significantly with increasing severity of the MGD (P=0.135 and 0.181, respectively).
Conclusion
There is importance for screening for dyslipidemia, BMI, and BG levels in MGD cases. |
| format | Article |
| id | doaj-art-d5c41bc3bbee4f99a7a41aed28513932 |
| institution | OA Journals |
| issn | 2090-4835 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delta Journal of Ophthalmology |
| spelling | doaj-art-d5c41bc3bbee4f99a7a41aed285139322025-08-20T02:31:37ZengWolters Kluwer Medknow PublicationsDelta Journal of Ophthalmology2090-48352024-04-01252616510.4103/djo.djo_81_23Dyslipidemia, body mass index, and blood glucose levels in patients with meibomian gland dysfunctionMeenu BabberReena SharmaBrijesh SinghVandana YadavRavi RanjanBackground Systemic dyslipidemia, obesity, and elevated blood sugars may theoretically affect the meibomian lipid composition and therefore, can cause meibomian gland dysfunction (MGD). Objective This study aimed to evaluate the association of serum lipid levels, body mass index (BMI), and serum blood glucose (BG) levels in patients with MGD compared with healthy controls. Patients and methods This is a comparative observational case-control study that enrolled 40 MGD patients (cases) and 40 controls. One eye of each participant was included in the study. After a detailed history, ocular examination was done by slit lamp biomicroscopy to grade/stage the MGD. The BMI, serum fasting total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, and BG levels were measured. Results The mean age of the cases was 46.75±10.93 years compared with 45.55±10.62 years in controls (P=0.620). Patients with MGD showed significantly higher serum fasting cholesterol (188.62±62.24 mg/dl),;Deg;BM;Deg;I (24.45±1.75 kg/m2), and fasting BG (110.35±32.30 mg/dl) compared with the controls (159.60±20.19 mg/dl, 23.45±1.35 kg/m2, and 98.43±27.69 mg/dl, respectively, P=0.022, 0.005, and 0.030, respectively). With increasing severity of MGD, the fasting serum cholesterol increased significantly from 136.73±24.88 mg/dl in grade 1 to 285.20±85.99 mg/dl in grade 4 (P<0.001) and the fasting serum LDL levels increased from 72.64±20.33 mg/dl in grade 1 to 202.60±95.66 mg/dl in grade 4 (P<0.001). In addition, the fasting serum triglycerides increased significantly as the severity of MGD increased from grade I (96.00±22.56 mg/dl) to grade III (227.09±83.44 mg/dl), (P<0.001). However, The fasting HDL and BG values did not increase significantly with increasing severity of the MGD (P=0.135 and 0.181, respectively). Conclusion There is importance for screening for dyslipidemia, BMI, and BG levels in MGD cases.https://journals.lww.com/djop/fulltext/2024/25020/dyslipidemia,_body_mass_index,_and_blood_glucose.1.aspxblood glucose; body mass index; dyslipidemia; meibomian gland dysfunction |
| spellingShingle | Meenu Babber Reena Sharma Brijesh Singh Vandana Yadav Ravi Ranjan Dyslipidemia, body mass index, and blood glucose levels in patients with meibomian gland dysfunction Delta Journal of Ophthalmology blood glucose; body mass index; dyslipidemia; meibomian gland dysfunction |
| title | Dyslipidemia, body mass index, and blood glucose levels in patients with meibomian gland dysfunction |
| title_full | Dyslipidemia, body mass index, and blood glucose levels in patients with meibomian gland dysfunction |
| title_fullStr | Dyslipidemia, body mass index, and blood glucose levels in patients with meibomian gland dysfunction |
| title_full_unstemmed | Dyslipidemia, body mass index, and blood glucose levels in patients with meibomian gland dysfunction |
| title_short | Dyslipidemia, body mass index, and blood glucose levels in patients with meibomian gland dysfunction |
| title_sort | dyslipidemia body mass index and blood glucose levels in patients with meibomian gland dysfunction |
| topic | blood glucose; body mass index; dyslipidemia; meibomian gland dysfunction |
| url | https://journals.lww.com/djop/fulltext/2024/25020/dyslipidemia,_body_mass_index,_and_blood_glucose.1.aspx |
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