Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit
IntroductionPreventive drugs for stress ulcers are widely and unreasonably used in the Intensive Care Unit (ICU). This study aims to examine the appropriate utilization of medications for stress ulcer prophylaxis (SUP) and identify factors that contribute to the inappropriate use of these medication...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1401335/full |
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| author | Pan Zhang Siyang Wang Tingting Zhi Naobei Ye Haonan Sun Xingyu Qin Shuhan Xu Ruiqin Zhang |
| author_facet | Pan Zhang Siyang Wang Tingting Zhi Naobei Ye Haonan Sun Xingyu Qin Shuhan Xu Ruiqin Zhang |
| author_sort | Pan Zhang |
| collection | DOAJ |
| description | IntroductionPreventive drugs for stress ulcers are widely and unreasonably used in the Intensive Care Unit (ICU). This study aims to examine the appropriate utilization of medications for stress ulcer prophylaxis (SUP) and identify factors that contribute to the inappropriate use of these medications in the ICU of the Second Hospital of Shanxi Medical University.MethodsPatient cases admitted to the ICU during the period from May 2022 to May 2023 were extracted from the hospital’s information management system. Single-factor analysis and multivariate logistic regression model analysis were performed using the SPSS to identify factors associated with inappropriate medication for prophylaxis. The efficacy of this predictive model was assessed through the use of the Receiver Operating Characteristic Curve (ROC), while the Hosmer test was utilized to evaluate the model fit.ResultsThis study included a total of 651 patient cases that met the inclusion criteria. Among these cases, 48.39% were found to have received inappropriate medication of SUP. The analysis revealed a significant association between inappropriate medication and partial transfer to departments (P < 0.05), as well as the use of anticoagulants (P = 0.009) in the prophylaxis group. In the non-prophylaxis group, the multifactorial logistic analysis indicated a significant correlation between inadequate prescriptions and partial transfer to departments (P < 0.05), as well as the presence of artificial airways (P < 0.01).ConclusionThere is a notable prevalence of inappropriate SUP in the ICU of this hospital. Attention should be paid to the SUP of some patients transferred to the department, the use of anticoagulants and the presence of artificial airway. |
| format | Article |
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| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-d5be15b9adf448e7a5971e473e1a300b2025-01-07T05:23:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14013351401335Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unitPan Zhang0Siyang Wang1Tingting Zhi2Naobei Ye3Haonan Sun4Xingyu Qin5Shuhan Xu6Ruiqin Zhang7College of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaCollege of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, ChinaCollege of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, ChinaCollege of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, ChinaThe Second Clinical Medicine School, Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaIntroductionPreventive drugs for stress ulcers are widely and unreasonably used in the Intensive Care Unit (ICU). This study aims to examine the appropriate utilization of medications for stress ulcer prophylaxis (SUP) and identify factors that contribute to the inappropriate use of these medications in the ICU of the Second Hospital of Shanxi Medical University.MethodsPatient cases admitted to the ICU during the period from May 2022 to May 2023 were extracted from the hospital’s information management system. Single-factor analysis and multivariate logistic regression model analysis were performed using the SPSS to identify factors associated with inappropriate medication for prophylaxis. The efficacy of this predictive model was assessed through the use of the Receiver Operating Characteristic Curve (ROC), while the Hosmer test was utilized to evaluate the model fit.ResultsThis study included a total of 651 patient cases that met the inclusion criteria. Among these cases, 48.39% were found to have received inappropriate medication of SUP. The analysis revealed a significant association between inappropriate medication and partial transfer to departments (P < 0.05), as well as the use of anticoagulants (P = 0.009) in the prophylaxis group. In the non-prophylaxis group, the multifactorial logistic analysis indicated a significant correlation between inadequate prescriptions and partial transfer to departments (P < 0.05), as well as the presence of artificial airways (P < 0.01).ConclusionThere is a notable prevalence of inappropriate SUP in the ICU of this hospital. Attention should be paid to the SUP of some patients transferred to the department, the use of anticoagulants and the presence of artificial airway.https://www.frontiersin.org/articles/10.3389/fphar.2024.1401335/fullstress ulcer prophylaxisintensive care unitrational drug useproton pump inhibitorsoperating characteristic curve |
| spellingShingle | Pan Zhang Siyang Wang Tingting Zhi Naobei Ye Haonan Sun Xingyu Qin Shuhan Xu Ruiqin Zhang Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit Frontiers in Pharmacology stress ulcer prophylaxis intensive care unit rational drug use proton pump inhibitors operating characteristic curve |
| title | Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit |
| title_full | Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit |
| title_fullStr | Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit |
| title_full_unstemmed | Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit |
| title_short | Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit |
| title_sort | appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit |
| topic | stress ulcer prophylaxis intensive care unit rational drug use proton pump inhibitors operating characteristic curve |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1401335/full |
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