Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma
Abstract Objectives Complete removal of the tumor and surrounding tissue is the most important prognostic factor such as survival after surgery. When the tumor invades the phrenic nerve, the impact of intraoperative phrenic nerve sacrifice on the short- and long-term prognosis of patients is not cle...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-025-03498-z |
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| author | Hongyun Ruan Xuehui Shang Dongjie Yan Bin Liu Fangchao Liu Zhi Yang |
| author_facet | Hongyun Ruan Xuehui Shang Dongjie Yan Bin Liu Fangchao Liu Zhi Yang |
| author_sort | Hongyun Ruan |
| collection | DOAJ |
| description | Abstract Objectives Complete removal of the tumor and surrounding tissue is the most important prognostic factor such as survival after surgery. When the tumor invades the phrenic nerve, the impact of intraoperative phrenic nerve sacrifice on the short- and long-term prognosis of patients is not clear. This study aims to explore the differences in prognosis between patients with malignant thymoma with and without phrenic nerve sacrifice during surgery, as well as analyze related factors. Methods A total of 209 patients who underwent thymoma resection in the Department of Thoracic Surgery at our hospital from February 2006 to November 2022 were collected for retrospective analysis. The groups were divided into two according to the presence or absence of intraoperative phrenic nerve sacrifice. A comparative analysis was conducted on postoperative complications, long-term survival recurrence between the two groups. Cox regression was used to analyze the factors related to the differences in short- and long-term prognosis between two groups. Results 29.6% of patients developed phrenic nerve sacrifice during thymoma surgery. Compared to patients without phrenic nerve sacrifice, the long-term survival rate was lower (P = 0.031). The independent risk factors for reduced long-term survival were intraoperative phrenic nerve sacrifice, secondary postoperative complications, and modified Masaoka staging III/IV. Conclusion Our data show that nearly one-third of patients develop phrenic nerve sacrifice during complete resection of thymoma. Phrenic nerve sacrifice has significant impact on short-term complications and long-term survival. Secondary postoperative complications and modified Masaoka staging III/IV are also risk factors for reduced long-term survival. |
| format | Article |
| id | doaj-art-d5bba2e50b1e409f8487c32848150634 |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-d5bba2e50b1e409f8487c328481506342025-02-02T12:06:44ZengBMCBMC Pulmonary Medicine1471-24662025-01-012511910.1186/s12890-025-03498-zComparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymomaHongyun Ruan0Xuehui Shang1Dongjie Yan2Bin Liu3Fangchao Liu4Zhi Yang5Department of Cellular and Molecular Biology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research InstituteDepartment of Hospital infection control, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research InstituteDepartment of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research InstituteDepartment of Cellular and Molecular Biology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research InstituteDepartment of Science and Technology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research InstituteDepartment of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research InstituteAbstract Objectives Complete removal of the tumor and surrounding tissue is the most important prognostic factor such as survival after surgery. When the tumor invades the phrenic nerve, the impact of intraoperative phrenic nerve sacrifice on the short- and long-term prognosis of patients is not clear. This study aims to explore the differences in prognosis between patients with malignant thymoma with and without phrenic nerve sacrifice during surgery, as well as analyze related factors. Methods A total of 209 patients who underwent thymoma resection in the Department of Thoracic Surgery at our hospital from February 2006 to November 2022 were collected for retrospective analysis. The groups were divided into two according to the presence or absence of intraoperative phrenic nerve sacrifice. A comparative analysis was conducted on postoperative complications, long-term survival recurrence between the two groups. Cox regression was used to analyze the factors related to the differences in short- and long-term prognosis between two groups. Results 29.6% of patients developed phrenic nerve sacrifice during thymoma surgery. Compared to patients without phrenic nerve sacrifice, the long-term survival rate was lower (P = 0.031). The independent risk factors for reduced long-term survival were intraoperative phrenic nerve sacrifice, secondary postoperative complications, and modified Masaoka staging III/IV. Conclusion Our data show that nearly one-third of patients develop phrenic nerve sacrifice during complete resection of thymoma. Phrenic nerve sacrifice has significant impact on short-term complications and long-term survival. Secondary postoperative complications and modified Masaoka staging III/IV are also risk factors for reduced long-term survival.https://doi.org/10.1186/s12890-025-03498-zThymomaSurgical resectionPhrenic nerve sacrificePrognosis |
| spellingShingle | Hongyun Ruan Xuehui Shang Dongjie Yan Bin Liu Fangchao Liu Zhi Yang Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma BMC Pulmonary Medicine Thymoma Surgical resection Phrenic nerve sacrifice Prognosis |
| title | Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma |
| title_full | Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma |
| title_fullStr | Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma |
| title_full_unstemmed | Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma |
| title_short | Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma |
| title_sort | comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma |
| topic | Thymoma Surgical resection Phrenic nerve sacrifice Prognosis |
| url | https://doi.org/10.1186/s12890-025-03498-z |
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