Endoscopic Ultrasound-Guided Fine Needle Biopsy with Stylet and Suction Versus No Stylet No Suction for the Diagnosis of Pancreatic and Non-Pancreatic Lesions
Marwa A Ahmed,1 Mohamed Yousri Ahmed,1 Hossam Eldin Shaaban,2 Sameh EA Abou Elenin,3 Ahmed Ali El-Habashi,1 Fatima Belabbes,4 Mohammed Tag-Adeen,5 Abeer Abdellatef,6 Hussein Hassan Okasha6 1National Cancer Institute (NCI), Cairo University, Cairo, Egypt; 2Department of Internal Medicine and Gastroen...
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Dove Medical Press
2025-06-01
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| author | Ahmed MA Ahmed MY Shaaban HE Abou Elenin SEA El-Habashi AA Belabbes F Tag-Adeen M Abdellatef A Okasha HH |
| author_facet | Ahmed MA Ahmed MY Shaaban HE Abou Elenin SEA El-Habashi AA Belabbes F Tag-Adeen M Abdellatef A Okasha HH |
| author_sort | Ahmed MA |
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| description | Marwa A Ahmed,1 Mohamed Yousri Ahmed,1 Hossam Eldin Shaaban,2 Sameh EA Abou Elenin,3 Ahmed Ali El-Habashi,1 Fatima Belabbes,4 Mohammed Tag-Adeen,5 Abeer Abdellatef,6 Hussein Hassan Okasha6 1National Cancer Institute (NCI), Cairo University, Cairo, Egypt; 2Department of Internal Medicine and Gastroenterology, National Hepatology and Tropical Medicine Research Institute, Cairo, 11796, Egypt; 3Gastroenterology Military Medical Academy, Cairo, 11796, Egypt; 4Department of Gastroenterology and Hepatology, Cheikh Khalifa International University Hospital, Mohammed VI University of Health and Sciences, Casablanca, and Research Entity, Mohammed VI Center for Research & Innovation, Rabat, Morocco; 5Division of Gastroenterology and Hepatology, Department of Internal Medicine, Qena Faculty of Medicine, South Valley University, Qena, Egypt; 6Department of Internal Medicine, Hepatogastroenterology division, Kasr Al-Aini Hospitals, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Hossam Eldin Shaaban, Email hsshaaban@aol.comBackground: Endoscopic ultrasound (EUS)-guided tissue acquisition is the procedure of choice to obtain samples to diagnose pancreatic and non-pancreatic lesions. Previous randomized trials demonstrated that using stylets during the EUS-fine needle biopsy (FNB) technique does not improve the diagnostic yield. However, little data exists regarding the role of stylet and suction in the core biopsy needle during EUS-guided tissue acquisition.Aim of the Study: This study aims to assess the efficacy and diagnostic yield of samples collected by EUS-FNB with stylet and suction versus no stylet, no suction techniques.Patients and Methods: This prospective study included 167 patients referred to the Gastroenterology Division, Internal Medicine Department, Kasr Al-Aini Hospitals for EUS-guided biopsy from pancreatic or non-pancreatic lesions from May 2021 to January 2024. Each lesion was sampled twice using an EUS-FNB 22-gauge Franseen-tip needle (Acquire; Boston Scientific, USA); one sample was collected with stylet and suction, while the other with no stylet no suction technique. Subsequently, slides were evaluated for cellularity, tissue integrity, degree of blood contamination, and diagnostic ability.Results: A total of 167 patients fulfilled the inclusion criteria, 78 females and 89 males, with a mean age of 61 years. Most lesions were pancreatic (83.2%, n = 139), while the remaining (16.8%, n = 28) were non-pancreatic. No significant differences were observed between stylet and suction versus no stylet, no suction techniques. The diagnostic performance, including sensitivity, specificity, and overall accuracy, was identical (100%) for both methods when evaluating alcohol-fixed smears in conjunction with formalin-preserved tissues collected through FNB.Conclusion: EUS-FNB tissue acquisition with and without stylet and suction provides comparable diagnostic yield and tissue quality for pancreatic and non-pancreatic lesions. The decision to use a stylet and suction should be individualized based on the clinical context and operator experience.Keywords: EUS-FNB, pancreatic lesions, non-pancreatic lesions, stylet, suction, diagnostic yield |
| format | Article |
| id | doaj-art-d5b172f8a9e14b2ba7a0b0003d024f96 |
| institution | Kabale University |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
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| series | International Journal of General Medicine |
| spelling | doaj-art-d5b172f8a9e14b2ba7a0b0003d024f962025-08-20T03:27:06ZengDove Medical PressInternational Journal of General Medicine1178-70742025-06-01Volume 18Issue 128512860103553Endoscopic Ultrasound-Guided Fine Needle Biopsy with Stylet and Suction Versus No Stylet No Suction for the Diagnosis of Pancreatic and Non-Pancreatic LesionsAhmed MA0Ahmed MY1Shaaban HE2Abou Elenin SEA3El-Habashi AA4Belabbes F5Tag-Adeen M6Abdellatef A7Okasha HH8PathologyPathologyDepartment of Internal Medicine and GastroenterologyGastroenterologyPathologyDepartment of Gastroenterology and HepatologyDivision of Gastroenterology and Hepatology, Department of Internal MedicineDepartment of Internal Medicine, Hepatogastroenterology divisionDepartment of Internal Medicine, Hepatogastroenterology divisionMarwa A Ahmed,1 Mohamed Yousri Ahmed,1 Hossam Eldin Shaaban,2 Sameh EA Abou Elenin,3 Ahmed Ali El-Habashi,1 Fatima Belabbes,4 Mohammed Tag-Adeen,5 Abeer Abdellatef,6 Hussein Hassan Okasha6 1National Cancer Institute (NCI), Cairo University, Cairo, Egypt; 2Department of Internal Medicine and Gastroenterology, National Hepatology and Tropical Medicine Research Institute, Cairo, 11796, Egypt; 3Gastroenterology Military Medical Academy, Cairo, 11796, Egypt; 4Department of Gastroenterology and Hepatology, Cheikh Khalifa International University Hospital, Mohammed VI University of Health and Sciences, Casablanca, and Research Entity, Mohammed VI Center for Research & Innovation, Rabat, Morocco; 5Division of Gastroenterology and Hepatology, Department of Internal Medicine, Qena Faculty of Medicine, South Valley University, Qena, Egypt; 6Department of Internal Medicine, Hepatogastroenterology division, Kasr Al-Aini Hospitals, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Hossam Eldin Shaaban, Email hsshaaban@aol.comBackground: Endoscopic ultrasound (EUS)-guided tissue acquisition is the procedure of choice to obtain samples to diagnose pancreatic and non-pancreatic lesions. Previous randomized trials demonstrated that using stylets during the EUS-fine needle biopsy (FNB) technique does not improve the diagnostic yield. However, little data exists regarding the role of stylet and suction in the core biopsy needle during EUS-guided tissue acquisition.Aim of the Study: This study aims to assess the efficacy and diagnostic yield of samples collected by EUS-FNB with stylet and suction versus no stylet, no suction techniques.Patients and Methods: This prospective study included 167 patients referred to the Gastroenterology Division, Internal Medicine Department, Kasr Al-Aini Hospitals for EUS-guided biopsy from pancreatic or non-pancreatic lesions from May 2021 to January 2024. Each lesion was sampled twice using an EUS-FNB 22-gauge Franseen-tip needle (Acquire; Boston Scientific, USA); one sample was collected with stylet and suction, while the other with no stylet no suction technique. Subsequently, slides were evaluated for cellularity, tissue integrity, degree of blood contamination, and diagnostic ability.Results: A total of 167 patients fulfilled the inclusion criteria, 78 females and 89 males, with a mean age of 61 years. Most lesions were pancreatic (83.2%, n = 139), while the remaining (16.8%, n = 28) were non-pancreatic. No significant differences were observed between stylet and suction versus no stylet, no suction techniques. The diagnostic performance, including sensitivity, specificity, and overall accuracy, was identical (100%) for both methods when evaluating alcohol-fixed smears in conjunction with formalin-preserved tissues collected through FNB.Conclusion: EUS-FNB tissue acquisition with and without stylet and suction provides comparable diagnostic yield and tissue quality for pancreatic and non-pancreatic lesions. The decision to use a stylet and suction should be individualized based on the clinical context and operator experience.Keywords: EUS-FNB, pancreatic lesions, non-pancreatic lesions, stylet, suction, diagnostic yieldhttps://www.dovepress.com/endoscopic-ultrasound-guided-fine-needle-biopsy-with-stylet-and-suctio-peer-reviewed-fulltext-article-IJGMEUS-FNBPancreatic lesionsNon-pancreatic lesionsStyletSuctionDiagnostic yield |
| spellingShingle | Ahmed MA Ahmed MY Shaaban HE Abou Elenin SEA El-Habashi AA Belabbes F Tag-Adeen M Abdellatef A Okasha HH Endoscopic Ultrasound-Guided Fine Needle Biopsy with Stylet and Suction Versus No Stylet No Suction for the Diagnosis of Pancreatic and Non-Pancreatic Lesions International Journal of General Medicine EUS-FNB Pancreatic lesions Non-pancreatic lesions Stylet Suction Diagnostic yield |
| title | Endoscopic Ultrasound-Guided Fine Needle Biopsy with Stylet and Suction Versus No Stylet No Suction for the Diagnosis of Pancreatic and Non-Pancreatic Lesions |
| title_full | Endoscopic Ultrasound-Guided Fine Needle Biopsy with Stylet and Suction Versus No Stylet No Suction for the Diagnosis of Pancreatic and Non-Pancreatic Lesions |
| title_fullStr | Endoscopic Ultrasound-Guided Fine Needle Biopsy with Stylet and Suction Versus No Stylet No Suction for the Diagnosis of Pancreatic and Non-Pancreatic Lesions |
| title_full_unstemmed | Endoscopic Ultrasound-Guided Fine Needle Biopsy with Stylet and Suction Versus No Stylet No Suction for the Diagnosis of Pancreatic and Non-Pancreatic Lesions |
| title_short | Endoscopic Ultrasound-Guided Fine Needle Biopsy with Stylet and Suction Versus No Stylet No Suction for the Diagnosis of Pancreatic and Non-Pancreatic Lesions |
| title_sort | endoscopic ultrasound guided fine needle biopsy with stylet and suction versus no stylet no suction for the diagnosis of pancreatic and non pancreatic lesions |
| topic | EUS-FNB Pancreatic lesions Non-pancreatic lesions Stylet Suction Diagnostic yield |
| url | https://www.dovepress.com/endoscopic-ultrasound-guided-fine-needle-biopsy-with-stylet-and-suctio-peer-reviewed-fulltext-article-IJGM |
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