Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole
Adenosine is a nucleoside which occurs naturally in a diverse forms in all cells of the body and in most biological fluids. Under basal conditions, the extracellular adenosine concentration is maintained within certain limits. Dipyridamol inhibits adenosine reuptake by erythrocytes, endothelial cel...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tikrit University
2022-12-01
|
| Series: | Tikrit Journal of Pure Science |
| Subjects: | |
| Online Access: | https://tjpsj.org/index.php/tjps/article/view/138 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849704196339662848 |
|---|---|
| author | Taghreed Hazem Saber Alfakje Ali Ashgar Abed AL_Mteewati Faehaa A. Al-Mashhadane |
| author_facet | Taghreed Hazem Saber Alfakje Ali Ashgar Abed AL_Mteewati Faehaa A. Al-Mashhadane |
| author_sort | Taghreed Hazem Saber Alfakje |
| collection | DOAJ |
| description |
Adenosine is a nucleoside which occurs naturally in a diverse forms in all cells of the body and in most biological fluids. Under basal conditions, the extracellular adenosine concentration is maintained within certain limits. Dipyridamol inhibits adenosine reuptake by erythrocytes, endothelial cells and platelet increasing plasma levels of adenosine Aims: study the effects of adenosine and dipyridamole on serum levels of serum urea, creatinine, alkaline phosphatase(ALP), lactate dehydrogenase (LDH), Aspartate Aminotransferase (GOT), and Alanine Aminotransferase (GPT). Material and methods: Thirty-five male rabbits were included in the study. The animals were divided into 3 groups: Group one(5 animals): injected intraperitoneal (i.p) with 2 ml of distilled water/day (control group). Group two (15 animals): were treated by i.p injection of adenosine, they were divided into 3 sub groups (5 animals) according to adenosine dose:1 mg/kg, 2mg/kg and 4 mg/kg.Group 3 (15 animals): were treated by dipyridamole orally, they were divided into 3 sub-groups (5 animals) according to dipyridamole dose:4 mg/kg, 8 mg/kg and 12 mg/kg. Result: Significant differences among 3 groups were found in blood urea, LDH, GOT levels, and in GPT levels. While statistical analysis of serum levels of S. creatinine and ALP showed no significant differences among 3 study groups. Conclusion: both adenosine, dipyridamole cause Significant differences among 3 groups were found in blood urea, LDH, GOT levels, and in GPT levels in rabbit
|
| format | Article |
| id | doaj-art-d5b083db14044133904eb249ef1e6786 |
| institution | DOAJ |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-d5b083db14044133904eb249ef1e67862025-08-20T03:16:51ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262022-12-0126310.25130/tjps.v26i3.138Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamoleTaghreed Hazem Saber AlfakjeAli Ashgar Abed AL_MteewatiFaehaa A. Al-Mashhadane Adenosine is a nucleoside which occurs naturally in a diverse forms in all cells of the body and in most biological fluids. Under basal conditions, the extracellular adenosine concentration is maintained within certain limits. Dipyridamol inhibits adenosine reuptake by erythrocytes, endothelial cells and platelet increasing plasma levels of adenosine Aims: study the effects of adenosine and dipyridamole on serum levels of serum urea, creatinine, alkaline phosphatase(ALP), lactate dehydrogenase (LDH), Aspartate Aminotransferase (GOT), and Alanine Aminotransferase (GPT). Material and methods: Thirty-five male rabbits were included in the study. The animals were divided into 3 groups: Group one(5 animals): injected intraperitoneal (i.p) with 2 ml of distilled water/day (control group). Group two (15 animals): were treated by i.p injection of adenosine, they were divided into 3 sub groups (5 animals) according to adenosine dose:1 mg/kg, 2mg/kg and 4 mg/kg.Group 3 (15 animals): were treated by dipyridamole orally, they were divided into 3 sub-groups (5 animals) according to dipyridamole dose:4 mg/kg, 8 mg/kg and 12 mg/kg. Result: Significant differences among 3 groups were found in blood urea, LDH, GOT levels, and in GPT levels. While statistical analysis of serum levels of S. creatinine and ALP showed no significant differences among 3 study groups. Conclusion: both adenosine, dipyridamole cause Significant differences among 3 groups were found in blood urea, LDH, GOT levels, and in GPT levels in rabbit https://tjpsj.org/index.php/tjps/article/view/138adenosinedipyridamolebiochemical markers |
| spellingShingle | Taghreed Hazem Saber Alfakje Ali Ashgar Abed AL_Mteewati Faehaa A. Al-Mashhadane Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole Tikrit Journal of Pure Science adenosine dipyridamole biochemical markers |
| title | Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole |
| title_full | Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole |
| title_fullStr | Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole |
| title_full_unstemmed | Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole |
| title_short | Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole |
| title_sort | effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits running title biochemical effects of adenosine and dipyridamole |
| topic | adenosine dipyridamole biochemical markers |
| url | https://tjpsj.org/index.php/tjps/article/view/138 |
| work_keys_str_mv | AT taghreedhazemsaberalfakje effectsofadenosineanddipyridamoleonserumlevelsofsomebiochemicalmarkersinrabbitsrunningtitlebiochemicaleffectsofadenosineanddipyridamole AT aliashgarabedalmteewati effectsofadenosineanddipyridamoleonserumlevelsofsomebiochemicalmarkersinrabbitsrunningtitlebiochemicaleffectsofadenosineanddipyridamole AT faehaaaalmashhadane effectsofadenosineanddipyridamoleonserumlevelsofsomebiochemicalmarkersinrabbitsrunningtitlebiochemicaleffectsofadenosineanddipyridamole |