Selective therapeutic hypothermia: A review of invasive and noninvasive techniques
OBJECTIVE: Therapeutic hypothermia is a promising treatment to prevent secondary neurologic injury. Clinical utility is limited by systemic complications of global hypothermia. Selective brain cooling remains a largely uninvestigated application. We review techniques of inducing selective brain cool...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2011-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700025&lng=en&tlng=en |
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| _version_ | 1850229664647217152 |
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| author | David Straus Vinay Prasad Lorenzo Munoz |
| author_facet | David Straus Vinay Prasad Lorenzo Munoz |
| author_sort | David Straus |
| collection | DOAJ |
| description | OBJECTIVE: Therapeutic hypothermia is a promising treatment to prevent secondary neurologic injury. Clinical utility is limited by systemic complications of global hypothermia. Selective brain cooling remains a largely uninvestigated application. We review techniques of inducing selective brain cooling. METHOD: Literature review. RESULTS: Strategies of inducing selective brain cooling were divided between non-invasive and invasive techniques. Non-invasive techniques were surface cooling and cooling via the upper airway. Invasive cooling methods include transvascular and compartmental (epidural, subdural, subarachnoid and intraventricular) cooling methods to remove heat from the brain. CONCLUSION: Selective brain cooling may offer the best strategy for achieving hypothermic neuroprotection. Non-invasive strategies have proven disappointing in human trials. There is a paucity of human experiments using invasive methods of selective brain cooling. Further application of invasive cooling strategies is needed. |
| format | Article |
| id | doaj-art-d5ad93fccea64e94a35b97f31f017074 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2011-12-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-d5ad93fccea64e94a35b97f31f0170742025-08-20T02:04:07ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272011-12-0169698198710.1590/S0004-282X2011000700025S0004-282X2011000700025Selective therapeutic hypothermia: A review of invasive and noninvasive techniquesDavid Straus0Vinay Prasad1Lorenzo Munoz2Rush UniversityNorthwestern UniversityRush UniversityOBJECTIVE: Therapeutic hypothermia is a promising treatment to prevent secondary neurologic injury. Clinical utility is limited by systemic complications of global hypothermia. Selective brain cooling remains a largely uninvestigated application. We review techniques of inducing selective brain cooling. METHOD: Literature review. RESULTS: Strategies of inducing selective brain cooling were divided between non-invasive and invasive techniques. Non-invasive techniques were surface cooling and cooling via the upper airway. Invasive cooling methods include transvascular and compartmental (epidural, subdural, subarachnoid and intraventricular) cooling methods to remove heat from the brain. CONCLUSION: Selective brain cooling may offer the best strategy for achieving hypothermic neuroprotection. Non-invasive strategies have proven disappointing in human trials. There is a paucity of human experiments using invasive methods of selective brain cooling. Further application of invasive cooling strategies is needed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700025&lng=en&tlng=enhipotermia terapêuticaresfriamento cerebral seletivoneuroproteçãohipotermia cerebral isolada |
| spellingShingle | David Straus Vinay Prasad Lorenzo Munoz Selective therapeutic hypothermia: A review of invasive and noninvasive techniques Arquivos de Neuro-Psiquiatria hipotermia terapêutica resfriamento cerebral seletivo neuroproteção hipotermia cerebral isolada |
| title | Selective therapeutic hypothermia: A review of invasive and noninvasive techniques |
| title_full | Selective therapeutic hypothermia: A review of invasive and noninvasive techniques |
| title_fullStr | Selective therapeutic hypothermia: A review of invasive and noninvasive techniques |
| title_full_unstemmed | Selective therapeutic hypothermia: A review of invasive and noninvasive techniques |
| title_short | Selective therapeutic hypothermia: A review of invasive and noninvasive techniques |
| title_sort | selective therapeutic hypothermia a review of invasive and noninvasive techniques |
| topic | hipotermia terapêutica resfriamento cerebral seletivo neuroproteção hipotermia cerebral isolada |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700025&lng=en&tlng=en |
| work_keys_str_mv | AT davidstraus selectivetherapeutichypothermiaareviewofinvasiveandnoninvasivetechniques AT vinayprasad selectivetherapeutichypothermiaareviewofinvasiveandnoninvasivetechniques AT lorenzomunoz selectivetherapeutichypothermiaareviewofinvasiveandnoninvasivetechniques |