A survey of computational approaches for characterizing microbial interactions in microbial mats

Abstract In this review, we use microbial mat communities as a general model system to highlight the strengths and limitations of current computational methods for analyzing interactions between members of microbial ecosystems. We describe the factors that make this environment have such a high degr...

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Main Authors: Vanesa L. Perillo, Michael Nute, Nicolae Sapoval, Kristen D. Curry, Logan Golia, Yongze Yin, Huw A. Ogilvie, Luay Nakhleh, Santiago Segarra, Devaki Bhaya, Diana G. Cuadrado, Todd J. Treangen
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Language:English
Published: BMC 2025-06-01
Series:Genome Biology
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Online Access:https://doi.org/10.1186/s13059-025-03634-2
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author Vanesa L. Perillo
Michael Nute
Nicolae Sapoval
Kristen D. Curry
Logan Golia
Yongze Yin
Huw A. Ogilvie
Luay Nakhleh
Santiago Segarra
Devaki Bhaya
Diana G. Cuadrado
Todd J. Treangen
author_facet Vanesa L. Perillo
Michael Nute
Nicolae Sapoval
Kristen D. Curry
Logan Golia
Yongze Yin
Huw A. Ogilvie
Luay Nakhleh
Santiago Segarra
Devaki Bhaya
Diana G. Cuadrado
Todd J. Treangen
author_sort Vanesa L. Perillo
collection DOAJ
description Abstract In this review, we use microbial mat communities as a general model system to highlight the strengths and limitations of current computational methods for analyzing interactions between members of microbial ecosystems. We describe the factors that make this environment have such a high degree of interaction, and we explore different categories of both laboratory and computational tools for studying these interactions. For each tool, we describe efforts to apply them to microbial mats in the past and, in the process, argue that genome-scale metabolic models have breakthrough potential for modeling microbial interactions in microbial mats.
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series Genome Biology
spelling doaj-art-d5a8bbddf32f4a2797fc024686bed6162025-08-20T03:47:14ZengBMCGenome Biology1474-760X2025-06-0126112010.1186/s13059-025-03634-2A survey of computational approaches for characterizing microbial interactions in microbial matsVanesa L. Perillo0Michael Nute1Nicolae Sapoval2Kristen D. Curry3Logan Golia4Yongze Yin5Huw A. Ogilvie6Luay Nakhleh7Santiago Segarra8Devaki Bhaya9Diana G. Cuadrado10Todd J. Treangen11Instituto Argentino de Oceanografía (IADO-CONICET-UNS)Department of Computer Science, Rice UniversityDepartment of Computer Science, Rice UniversityDepartment of Computer Science, Rice UniversityDepartment of Computer Science, Rice UniversityDepartment of Computer Science, Rice UniversityDepartment of Computer Science, Rice UniversityDepartment of Computer Science, Rice UniversityDepartment of Electrical and Computer Engineering, Rice UniversityDepartment of Plant Biology, Carnegie Institution for ScienceInstituto Argentino de Oceanografía (IADO-CONICET-UNS)Department of Computer Science, Rice UniversityAbstract In this review, we use microbial mat communities as a general model system to highlight the strengths and limitations of current computational methods for analyzing interactions between members of microbial ecosystems. We describe the factors that make this environment have such a high degree of interaction, and we explore different categories of both laboratory and computational tools for studying these interactions. For each tool, we describe efforts to apply them to microbial mats in the past and, in the process, argue that genome-scale metabolic models have breakthrough potential for modeling microbial interactions in microbial mats.https://doi.org/10.1186/s13059-025-03634-2Transdisciplinary studiesComputational modelsMicrobial matsMicrobial evolutionEnvironmental dataMicrobial ecology
spellingShingle Vanesa L. Perillo
Michael Nute
Nicolae Sapoval
Kristen D. Curry
Logan Golia
Yongze Yin
Huw A. Ogilvie
Luay Nakhleh
Santiago Segarra
Devaki Bhaya
Diana G. Cuadrado
Todd J. Treangen
A survey of computational approaches for characterizing microbial interactions in microbial mats
Genome Biology
Transdisciplinary studies
Computational models
Microbial mats
Microbial evolution
Environmental data
Microbial ecology
title A survey of computational approaches for characterizing microbial interactions in microbial mats
title_full A survey of computational approaches for characterizing microbial interactions in microbial mats
title_fullStr A survey of computational approaches for characterizing microbial interactions in microbial mats
title_full_unstemmed A survey of computational approaches for characterizing microbial interactions in microbial mats
title_short A survey of computational approaches for characterizing microbial interactions in microbial mats
title_sort survey of computational approaches for characterizing microbial interactions in microbial mats
topic Transdisciplinary studies
Computational models
Microbial mats
Microbial evolution
Environmental data
Microbial ecology
url https://doi.org/10.1186/s13059-025-03634-2
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