Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat
Management of chronic non-healing wounds in cats requires a comprehensive approach. This report describes the treatment of a severe open skin wound on the skull using a combined approach involving allogeneic adipose-derived mesenchymal stem cells (MSCs) and autologous platelet-rich plasma (PRP). A 1...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2025-04-01
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| Series: | Veterinární Medicína |
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| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-202504-0002_allogeneic-adipose-mscs-and-autologous-prp-for-chronic-non-healing-wound-in-a-cat.php |
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| author | N Suwan S Jenjittikul R Tiratrakoonseree C Jiradanaipat S Teerawongsuwan Wi Phathomrapeepong W Phanwanich R Rungsiwiwut |
| author_facet | N Suwan S Jenjittikul R Tiratrakoonseree C Jiradanaipat S Teerawongsuwan Wi Phathomrapeepong W Phanwanich R Rungsiwiwut |
| author_sort | N Suwan |
| collection | DOAJ |
| description | Management of chronic non-healing wounds in cats requires a comprehensive approach. This report describes the treatment of a severe open skin wound on the skull using a combined approach involving allogeneic adipose-derived mesenchymal stem cells (MSCs) and autologous platelet-rich plasma (PRP). A 12-year-old neutered male mixed-breed domestic cat presented with a non-healing chronic wound on the skull. The wound extended from the orbital to the occipital area and from the left to the right temporal region. Laboratory test results were positive for feline immunodeficiency virus and impaired kidney function. Sensitivity tests revealed resistance to several antibiotics. Due to limited skin reconstruction options, MSCs were administered subcutaneously at the wound edge once a month for three months. PRP was collected one month after the initial MSC administration and injected at the wound edge monthly between MSC treatments. The wound diameter was measured daily during saline cleaning. The cat received protein-supplemented food daily. Wound healing was observed two weeks after the MSC administration, gradually decreasing in size and closing completely within 5 months. This case demonstrates the successful application of MSCs and PRP for treating chronic wounds in cats. |
| format | Article |
| id | doaj-art-d5a8a42f03ce4e098912f1f404d49685 |
| institution | OA Journals |
| issn | 0375-8427 1805-9392 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj-art-d5a8a42f03ce4e098912f1f404d496852025-08-20T01:47:37ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922025-04-0170414314910.17221/93/2024-VETMEDvet-202504-0002Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a catN Suwan0https://orcid.org/0009-0002-2432-6593S Jenjittikul1https://orcid.org/0009-0008-5362-7831R Tiratrakoonseree2https://orcid.org/0009-0004-6657-6579C Jiradanaipat3https://orcid.org/0009-0003-1557-0612S Teerawongsuwan4https://orcid.org/0009-0000-5942-4391Wi Phathomrapeepong5https://orcid.org/0009-0004-2763-9223W Phanwanich6https://orcid.org/0009-0006-8234-828XR Rungsiwiwut7https://orcid.org/0000-0002-1448-2309Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, ThailandFaculty of Medicine, Srinakharinwirot University, Nakhon Nayok, ThailandFaculty of Medicine, Srinakharinwirot University, Nakhon Nayok, ThailandFaculty of Medicine, Srinakharinwirot University, Nakhon Nayok, ThailandDepartment of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, ThailandWipawadee animal clinic, Bangkok, ThailandDepartment of Biomedical Engineering, Faculty of Engineer, Mahidol University, Nakhon Pathom, ThailandDepartment of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, ThailandManagement of chronic non-healing wounds in cats requires a comprehensive approach. This report describes the treatment of a severe open skin wound on the skull using a combined approach involving allogeneic adipose-derived mesenchymal stem cells (MSCs) and autologous platelet-rich plasma (PRP). A 12-year-old neutered male mixed-breed domestic cat presented with a non-healing chronic wound on the skull. The wound extended from the orbital to the occipital area and from the left to the right temporal region. Laboratory test results were positive for feline immunodeficiency virus and impaired kidney function. Sensitivity tests revealed resistance to several antibiotics. Due to limited skin reconstruction options, MSCs were administered subcutaneously at the wound edge once a month for three months. PRP was collected one month after the initial MSC administration and injected at the wound edge monthly between MSC treatments. The wound diameter was measured daily during saline cleaning. The cat received protein-supplemented food daily. Wound healing was observed two weeks after the MSC administration, gradually decreasing in size and closing completely within 5 months. This case demonstrates the successful application of MSCs and PRP for treating chronic wounds in cats.https://vetmed.agriculturejournals.cz/artkey/vet-202504-0002_allogeneic-adipose-mscs-and-autologous-prp-for-chronic-non-healing-wound-in-a-cat.phpbite woundregenerative veterinary medicinestem cells |
| spellingShingle | N Suwan S Jenjittikul R Tiratrakoonseree C Jiradanaipat S Teerawongsuwan Wi Phathomrapeepong W Phanwanich R Rungsiwiwut Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat Veterinární Medicína bite wound regenerative veterinary medicine stem cells |
| title | Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat |
| title_full | Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat |
| title_fullStr | Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat |
| title_full_unstemmed | Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat |
| title_short | Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat |
| title_sort | allogeneic adipose mscs and autologous prp for chronic non healing wound in a cat |
| topic | bite wound regenerative veterinary medicine stem cells |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-202504-0002_allogeneic-adipose-mscs-and-autologous-prp-for-chronic-non-healing-wound-in-a-cat.php |
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