Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India
Introduction Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia with specific molecular pathogenesis, clinical features, and treatment. It is cytogenetically characterized by translocation t (15;17) (q24;q21). The location of breakpoints within the PML gene determin...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2025-06-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1801738 |
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| author | Shweta Gondha Prerna Walia Beena Brahmbhatt Jayendrakumar Patel Toral Mandalia Disha Jethva |
| author_facet | Shweta Gondha Prerna Walia Beena Brahmbhatt Jayendrakumar Patel Toral Mandalia Disha Jethva |
| author_sort | Shweta Gondha |
| collection | DOAJ |
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Introduction Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia with specific molecular pathogenesis, clinical features, and treatment. It is cytogenetically characterized by translocation t (15;17) (q24;q21). The location of breakpoints within the PML gene determines the formation of distinct promyelocytic leukemia-retinoic acid receptor α (PML-RARα) transcript subtypes which have prognostic significance. Breakpoints in intron 6 result in the long (L or bcr-1) subtype, those in exon 6 produce the variant (V or bcr-2) subtype, and breakpoints in intron 3 lead to the short (S or bcr-3) subtype. |
| format | Article |
| id | doaj-art-d5a5bbdef6c0474290f930fc64452ada |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-d5a5bbdef6c0474290f930fc64452ada2025-08-20T02:22:34ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292025-06-01460331231710.1055/s-0044-1801738Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western IndiaShweta Gondha0Prerna Walia1Beena Brahmbhatt2Jayendrakumar Patel3Toral Mandalia4Disha Jethva5Department of Oncopathology, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, IndiaDepartment of Oncopathology, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, IndiaDepartment of Oncopathology, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, IndiaMolecular Diagnostic and Research Lab, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, IndiaMolecular Diagnostic and Research Lab, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, IndiaMolecular Diagnostic and Research Lab, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India Introduction Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia with specific molecular pathogenesis, clinical features, and treatment. It is cytogenetically characterized by translocation t (15;17) (q24;q21). The location of breakpoints within the PML gene determines the formation of distinct promyelocytic leukemia-retinoic acid receptor α (PML-RARα) transcript subtypes which have prognostic significance. Breakpoints in intron 6 result in the long (L or bcr-1) subtype, those in exon 6 produce the variant (V or bcr-2) subtype, and breakpoints in intron 3 lead to the short (S or bcr-3) subtype.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1801738acute promyelocytic leukemiaPML-RARα transcriptsbcr-3 transcript |
| spellingShingle | Shweta Gondha Prerna Walia Beena Brahmbhatt Jayendrakumar Patel Toral Mandalia Disha Jethva Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India Indian Journal of Medical and Paediatric Oncology acute promyelocytic leukemia PML-RARα transcripts bcr-3 transcript |
| title | Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India |
| title_full | Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India |
| title_fullStr | Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India |
| title_full_unstemmed | Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India |
| title_short | Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India |
| title_sort | pattern of expression of pml rarα transcripts in acute promyelocytic leukemia patients and its correlation with overall survival a retrospective study from western india |
| topic | acute promyelocytic leukemia PML-RARα transcripts bcr-3 transcript |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1801738 |
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