A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery
Abstract Increasing evidence suggests vaginal dysbiosis is associated with persistent high-risk human papillomavirus (hrHPV) infection and cervical intraepithelial neoplasia (CIN) development. In this pilot longitudinal study, we investigate the potential of vaginal microbiome biomarkers to predict...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08328-w |
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| author | Cristiana Banila Efthymios Ladoukakis Dorota Scibior-Bentkowska Leandro Rodrigues Santiago Caroline Reuter Michelle Kleeman Belinda Nedjai |
| author_facet | Cristiana Banila Efthymios Ladoukakis Dorota Scibior-Bentkowska Leandro Rodrigues Santiago Caroline Reuter Michelle Kleeman Belinda Nedjai |
| author_sort | Cristiana Banila |
| collection | DOAJ |
| description | Abstract Increasing evidence suggests vaginal dysbiosis is associated with persistent high-risk human papillomavirus (hrHPV) infection and cervical intraepithelial neoplasia (CIN) development. In this pilot longitudinal study, we investigate the potential of vaginal microbiome biomarkers to predict CIN3 development in hrHPV-positive (hrHPV+) women of reproductive age and assess loop electrosurgical excision procedure (LEEP) outcomes. Fifty-nine non-menopausal women 20–53 years old, with normal cytology, were selected from the ARTISTIC trial and followed up twice over six years. Vaginal microbiome was analysed by 16S rRNA sequencing. HrHPV+ women with CIN3 showed a significant overrepresentation of Sneathia amnii, Megasphaera genomosp., Peptostreptococcus anaerobius and Achromobacter spanius (p < 0.05). Successfully LEEP-treated hrHPV-negative women exhibited increased Lactobacillus species, especially Lactobacillus gasseri. Additionally, Lactobacillus helveticus, suntoryeus and vaginalis showed a potential protective role against CIN3 development. These unique microbial biomarkers associated with CIN3 development and recovery following LEEP treatment bring new insights into the vaginal microbiome’s role on disease progression. |
| format | Article |
| id | doaj-art-d5a4e6b2594c4b958a06a092f0342678 |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-d5a4e6b2594c4b958a06a092f03426782025-08-20T02:05:42ZengNature PortfolioCommunications Biology2399-36422025-06-018111010.1038/s42003-025-08328-wA longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recoveryCristiana Banila0Efthymios Ladoukakis1Dorota Scibior-Bentkowska2Leandro Rodrigues Santiago3Caroline Reuter4Michelle Kleeman5Belinda Nedjai6Wolfson Institute of Population Health, Queen Mary University of LondonWolfson Institute of Population Health, Queen Mary University of LondonWolfson Institute of Population Health, Queen Mary University of LondonThe Institute of Cancer Research (ICR), Genomics FacilityWolfson Institute for Biomedical Research, University College LondonGuy’s and St. Thomas NHS Foundation TrustWolfson Institute of Population Health, Queen Mary University of LondonAbstract Increasing evidence suggests vaginal dysbiosis is associated with persistent high-risk human papillomavirus (hrHPV) infection and cervical intraepithelial neoplasia (CIN) development. In this pilot longitudinal study, we investigate the potential of vaginal microbiome biomarkers to predict CIN3 development in hrHPV-positive (hrHPV+) women of reproductive age and assess loop electrosurgical excision procedure (LEEP) outcomes. Fifty-nine non-menopausal women 20–53 years old, with normal cytology, were selected from the ARTISTIC trial and followed up twice over six years. Vaginal microbiome was analysed by 16S rRNA sequencing. HrHPV+ women with CIN3 showed a significant overrepresentation of Sneathia amnii, Megasphaera genomosp., Peptostreptococcus anaerobius and Achromobacter spanius (p < 0.05). Successfully LEEP-treated hrHPV-negative women exhibited increased Lactobacillus species, especially Lactobacillus gasseri. Additionally, Lactobacillus helveticus, suntoryeus and vaginalis showed a potential protective role against CIN3 development. These unique microbial biomarkers associated with CIN3 development and recovery following LEEP treatment bring new insights into the vaginal microbiome’s role on disease progression.https://doi.org/10.1038/s42003-025-08328-w |
| spellingShingle | Cristiana Banila Efthymios Ladoukakis Dorota Scibior-Bentkowska Leandro Rodrigues Santiago Caroline Reuter Michelle Kleeman Belinda Nedjai A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery Communications Biology |
| title | A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery |
| title_full | A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery |
| title_fullStr | A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery |
| title_full_unstemmed | A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery |
| title_short | A longitudinal pilot study in pre-menopausal women links cervicovaginal microbiome to CIN3 progression and recovery |
| title_sort | longitudinal pilot study in pre menopausal women links cervicovaginal microbiome to cin3 progression and recovery |
| url | https://doi.org/10.1038/s42003-025-08328-w |
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