Clinical significance of ICAM-1,VCAM-1 and PECAM-1 in vascular endothelial injury of end-stage renal disease patients
Objective To compare the serum levels of ICAM-1,VCAM-1 and PECAM-1 between maintenance dialysis and non-dialysis end-stage renal disease（ESRD）patients and explore the effect of dialysis versusnon-dialysis on vascular endothelial damage.Methods A total of 71 ESRD patients were selected and divided in...
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| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57905246&Fpath=home&index=0 |
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| Summary: | Objective To compare the serum levels of ICAM-1,VCAM-1 and PECAM-1 between maintenance dialysis and non-dialysis end-stage renal disease（ESRD）patients and explore the effect of dialysis versusnon-dialysis on vascular endothelial damage.Methods A total of 71 ESRD patients were selected and divided into two groups of MHD（n=35）and N-HD（n=36）.At the same time, 20 cases of normal control group（group C）were selected.And 5 mL of venous blood was harvested from normal control and non-dialysis groups in the morning under a fasting state.Also 5 mL of venous blood was collected from dialysis group on the day of dialysis from the side of internal fistula under a fasting state.The samples were submitted to the biochemical room for blood routine, parathyroid hormone（PTH）,hepato-renal function, blood glucose, blood lipid and electrolytes.Another 4 mL of venous blood was tested for the values of ICAM-1,VCAM-1 and PECAM-1 by double antibody sandwich enzyme-linked immunosorbent assay（ELISA）.Results Among three groups, no significant difference existed in gender, age or etiology（all P>0.05）.And significant differences existed in hemoglobin（Hb）,PTH,blood phosphorus, albumin（Alb）,triglyceride（TG）,total cholesterol（TC）,low-density lipoprotein（LDL）,blood urea nitrogen（BUN）,creatinine（Cr）and uric acid（UA）（all P<0.05）.Also significant differences existed between MHD and control groups（all P<0.05）;And significant differences existed in the above parameters between N-HD and control groups（all P<0.05）.PTH,BUN,Cr and UA in N-HD group were significantly higher than those in MHD group（all P<0.05）.No significant differences existed in Hb, serum calcium, phosphorus, ALB,TG,LDL and high-density lipoprotein（HDL）between MHD and N-HD groups（both P>0.05）.ICAM-1,VCAM-1 and PECAM-1 were higher in MHD group than those in control group（all P<0.05）.ICAM-1,VCAM-1 and PECAM-1 were higher in N-HD group than those in control group（all P<0.05）.ICAM-1,VCAM-1 and PECAM-1 were significantly higher in N-HD group than those in MHD group（all P<0.05）.Conclusion The serum expressions of ICAM-1,VCAM-1 and PECAM-1 in ESRD patients with MHD are lower than those in N-HD patients.It indicates that maintenance hemodialysis has a protective effect on vascular endothelial injury in ESRD patients. |
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| ISSN: | 1671-2390 |