Interplay between circadian rhythm, ageing and neurodegenerative disorder
Circadian rhythm, as a homeostatic tool of biological life, plays a vital role in regulating human physiology, metabolism, endocrinology, and emotional and cognitive behaviour. A disrupted circadian rhythm, marked by age-related alterations such as decreased variation in sleep–wake patterns and inst...
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| Format: | Article |
| Language: | English |
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The Royal Society
2025-07-01
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| Series: | Open Biology |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.240161 |
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| author | Aarti Nagayach Rakesh Bhaskar Shampa Ghosh Dhivyadharshni M Mosleh Mohammad Abomughaid Sung Soo Han Krishna Kumar Singh Abdulmajeed G. Almutary Kamlesh Chaudhary Shikha Atteri Ashish Singh Chauhan Niraj Kumar Jha Jitendra Kumar Sinha |
| author_facet | Aarti Nagayach Rakesh Bhaskar Shampa Ghosh Dhivyadharshni M Mosleh Mohammad Abomughaid Sung Soo Han Krishna Kumar Singh Abdulmajeed G. Almutary Kamlesh Chaudhary Shikha Atteri Ashish Singh Chauhan Niraj Kumar Jha Jitendra Kumar Sinha |
| author_sort | Aarti Nagayach |
| collection | DOAJ |
| description | Circadian rhythm, as a homeostatic tool of biological life, plays a vital role in regulating human physiology, metabolism, endocrinology, and emotional and cognitive behaviour. A disrupted circadian rhythm, marked by age-related alterations such as decreased variation in sleep–wake patterns and instability in the timing of these patterns, can worsen age-related problems such as increased oxidative stress and inflammation. Advancing age is associated with anomalies in the redox balance, gradual alterations in physiological functions and deregulation of various metabolic pathways. The mutual interaction between circadian rhythm and ageing may potentially contribute to the development of neurodegenerative disorders. Consistent alterations in circadian rhythms could lead to various degenerative disorders and aggravate age-related ailments. Therefore, understanding and unravelling the intricate interplay between circadian rhythm and ageing holds immense potential for developing therapeutic interventions and promoting healthy ageing strategies. In this review article, we discuss the role of circadian rhythms in physiology and their age-related changes that impact health. We focus on how disruptions in circadian rhythms, common with ageing, may increase risks for neurodegenerative disorders. Understanding this interaction holds promise for developing therapeutic approaches to support healthy ageing. |
| format | Article |
| id | doaj-art-d59e8f8efaf04697b99db390e35b3f67 |
| institution | Kabale University |
| issn | 2046-2441 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj-art-d59e8f8efaf04697b99db390e35b3f672025-08-20T03:55:53ZengThe Royal SocietyOpen Biology2046-24412025-07-0115710.1098/rsob.240161Interplay between circadian rhythm, ageing and neurodegenerative disorderAarti Nagayach0Rakesh Bhaskar1Shampa Ghosh2Dhivyadharshni M3Mosleh Mohammad Abomughaid4Sung Soo Han5Krishna Kumar Singh6Abdulmajeed G. Almutary7Kamlesh Chaudhary8Shikha Atteri9Ashish Singh Chauhan10Niraj Kumar Jha11Jitendra Kumar Sinha12Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USASchool of Chemical Engineering, Yeungnam University, Gyeonsang 38541, Republic of KoreaGloNeuro, Sector 107, Vishwakarma Road, Noida, Uttar Pradesh 201301, IndiaCentre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha 61922, Saudi ArabiaSchool of Chemical Engineering, Yeungnam University, Gyeonsang 38541, Republic of KoreaSymbiosis Centre for Information Technology (SCIT), Rajiv Gandhi InfoTech Park, Hinjawadi, Pune, Maharashtra 411057, IndiaDepartment of Biomedical Sciences, College of Health Sciences, Abu Dhabi University, Abu Dhabi 59911, United Arab EmiratesDepartment of Neurology, National Institute of Medical Sciences, NIMS University, Jaipur, Rajasthan, IndiaChandigarh Pharmacy College, Chandigarh Group of Colleges Jhanjeri, Mohali, Punjab, IndiaUttaranchal Institute of Pharmaceutical Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, IndiaDepartment of Biotechnology & Bioengineering, School of Biosciences & Technology, Galgotias University, Greater Noida, Uttar Pradesh 203201, IndiaGloNeuro, Sector 107, Vishwakarma Road, Noida, Uttar Pradesh 201301, IndiaCircadian rhythm, as a homeostatic tool of biological life, plays a vital role in regulating human physiology, metabolism, endocrinology, and emotional and cognitive behaviour. A disrupted circadian rhythm, marked by age-related alterations such as decreased variation in sleep–wake patterns and instability in the timing of these patterns, can worsen age-related problems such as increased oxidative stress and inflammation. Advancing age is associated with anomalies in the redox balance, gradual alterations in physiological functions and deregulation of various metabolic pathways. The mutual interaction between circadian rhythm and ageing may potentially contribute to the development of neurodegenerative disorders. Consistent alterations in circadian rhythms could lead to various degenerative disorders and aggravate age-related ailments. Therefore, understanding and unravelling the intricate interplay between circadian rhythm and ageing holds immense potential for developing therapeutic interventions and promoting healthy ageing strategies. In this review article, we discuss the role of circadian rhythms in physiology and their age-related changes that impact health. We focus on how disruptions in circadian rhythms, common with ageing, may increase risks for neurodegenerative disorders. Understanding this interaction holds promise for developing therapeutic approaches to support healthy ageing.https://royalsocietypublishing.org/doi/10.1098/rsob.240161endogenous rhythmhealthy ageinglongevitysleep–wake cycleoxidative stressneurodegeneration |
| spellingShingle | Aarti Nagayach Rakesh Bhaskar Shampa Ghosh Dhivyadharshni M Mosleh Mohammad Abomughaid Sung Soo Han Krishna Kumar Singh Abdulmajeed G. Almutary Kamlesh Chaudhary Shikha Atteri Ashish Singh Chauhan Niraj Kumar Jha Jitendra Kumar Sinha Interplay between circadian rhythm, ageing and neurodegenerative disorder Open Biology endogenous rhythm healthy ageing longevity sleep–wake cycle oxidative stress neurodegeneration |
| title | Interplay between circadian rhythm, ageing and neurodegenerative disorder |
| title_full | Interplay between circadian rhythm, ageing and neurodegenerative disorder |
| title_fullStr | Interplay between circadian rhythm, ageing and neurodegenerative disorder |
| title_full_unstemmed | Interplay between circadian rhythm, ageing and neurodegenerative disorder |
| title_short | Interplay between circadian rhythm, ageing and neurodegenerative disorder |
| title_sort | interplay between circadian rhythm ageing and neurodegenerative disorder |
| topic | endogenous rhythm healthy ageing longevity sleep–wake cycle oxidative stress neurodegeneration |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.240161 |
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