Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass
Dedifferentiated liposarcomas most commonly arise in the retroperitoneum, accounting for 10% of liposarcomas. Heterologous differentiation occurs in 5-10% of dedifferentiated liposarcomas; however, divergent osteosarcomatous differentiation is rare. We report a rare case of initial presentation of d...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/8025103 |
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| author | Jeenal Gordhandas Grace Lin Ann M. P. Tipps Somaye Y. Zare |
| author_facet | Jeenal Gordhandas Grace Lin Ann M. P. Tipps Somaye Y. Zare |
| author_sort | Jeenal Gordhandas |
| collection | DOAJ |
| description | Dedifferentiated liposarcomas most commonly arise in the retroperitoneum, accounting for 10% of liposarcomas. Heterologous differentiation occurs in 5-10% of dedifferentiated liposarcomas; however, divergent osteosarcomatous differentiation is rare. We report a rare case of initial presentation of dedifferentiated liposarcoma with osteosarcomatous component as a colonic mass in a 72-year-old man. The tumor is mainly composed of bony trabeculae with intervening highly atypical cells and adjacent high-grade mesenchymal nonlipogenic tumor, as well as areas of well-differentiated liposarcoma. Immunohistochemical studies showed diffuse positivity for SATB2 in the atypical cells and fluorescence in situ hybridization revealed high-level amplification of MDM2 gene, supporting the diagnosis of well-differentiated and dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation. |
| format | Article |
| id | doaj-art-d59a8eaeb4964fba9950680995ae7271 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-d59a8eaeb4964fba9950680995ae72712025-02-03T05:59:40ZengWileyCase Reports in Pathology2090-67812090-679X2019-01-01201910.1155/2019/80251038025103Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic MassJeenal Gordhandas0Grace Lin1Ann M. P. Tipps2Somaye Y. Zare3Department of Pathology, University of California San Diego, La Jolla, San Diego, CA, USADepartment of Pathology, University of California San Diego, La Jolla, San Diego, CA, USADepartment of Pathology, University of California San Diego, La Jolla, San Diego, CA, USADepartment of Pathology, University of California San Diego, La Jolla, San Diego, CA, USADedifferentiated liposarcomas most commonly arise in the retroperitoneum, accounting for 10% of liposarcomas. Heterologous differentiation occurs in 5-10% of dedifferentiated liposarcomas; however, divergent osteosarcomatous differentiation is rare. We report a rare case of initial presentation of dedifferentiated liposarcoma with osteosarcomatous component as a colonic mass in a 72-year-old man. The tumor is mainly composed of bony trabeculae with intervening highly atypical cells and adjacent high-grade mesenchymal nonlipogenic tumor, as well as areas of well-differentiated liposarcoma. Immunohistochemical studies showed diffuse positivity for SATB2 in the atypical cells and fluorescence in situ hybridization revealed high-level amplification of MDM2 gene, supporting the diagnosis of well-differentiated and dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation.http://dx.doi.org/10.1155/2019/8025103 |
| spellingShingle | Jeenal Gordhandas Grace Lin Ann M. P. Tipps Somaye Y. Zare Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass Case Reports in Pathology |
| title | Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass |
| title_full | Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass |
| title_fullStr | Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass |
| title_full_unstemmed | Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass |
| title_short | Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass |
| title_sort | osteosarcomatous divergence in dedifferentiated liposarcoma presenting as a colonic mass |
| url | http://dx.doi.org/10.1155/2019/8025103 |
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