Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche

Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche

The gastrointestinal epithelium is characterized by a high turnover of cells and intestinal stem cells predominantly reside at the bottom of crypts and their progeny serve to maintain normal intestinal homeostasis. Accumulating evidence demonstrates the pivotal role of a niche surrounding intestinal...

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Main Authors: Agnieszka Pastuła, Moritz Middelhoff, Anna Brandtner, Moritz Tobiasch, Bettina Höhl, Andreas H. Nuber, Ihsan Ekin Demir, Steffi Neupert, Patrick Kollmann, Gemma Mazzuoli-Weber, Michael Quante
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2016/3710836
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