Molecular Surveillance for Potential Zoonotic Pathogens in Troglophilus Bats: Detection and Molecular Characterization of Bat Coronaviruses in Southern Italy

The recent COVID-19 pandemic has renewed interest in bats, as they are natural hosts for numerous viruses, some of which have crossed species boundaries. Despite continued efforts in the past, the ecology of bat-related viruses in a significant part of national territories, such as Italy, remains la...

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Main Authors: Francesco Mira, Francesca Gucciardi, Giorgia Schiró, Rosario Grasso, Maria Teresa Spena, Gábor Kemenesi, Claudia Vaiana, Davide Anzá, Laura Di Paola, Santina Di Bella, Annalisa Guercio, Giuseppa Purpari
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Language:English
Published: MDPI AG 2025-05-01
Series:Pathogens
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Online Access:https://www.mdpi.com/2076-0817/14/5/457
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author Francesco Mira
Francesca Gucciardi
Giorgia Schiró
Rosario Grasso
Maria Teresa Spena
Gábor Kemenesi
Claudia Vaiana
Davide Anzá
Laura Di Paola
Santina Di Bella
Annalisa Guercio
Giuseppa Purpari
author_facet Francesco Mira
Francesca Gucciardi
Giorgia Schiró
Rosario Grasso
Maria Teresa Spena
Gábor Kemenesi
Claudia Vaiana
Davide Anzá
Laura Di Paola
Santina Di Bella
Annalisa Guercio
Giuseppa Purpari
author_sort Francesco Mira
collection DOAJ
description The recent COVID-19 pandemic has renewed interest in bats, as they are natural hosts for numerous viruses, some of which have crossed species boundaries. Despite continued efforts in the past, the ecology of bat-related viruses in a significant part of national territories, such as Italy, remains largely unexplored. Herein, we describe the detection and molecular characterization of bat coronaviruses, identified during a viral survey on selected potential zoonotic pathogens (lyssavirus and coronaviruses) carried out in Sicily, southern Italy. A total number of 330 samples were collected from 149 bats in a period (November 2020–April 2023) overlapping the COVID-19 pandemic. All samples tested negative for lyssavirus and SARS-CoV-2, while 12 bats (8.05%) tested positive to a pan-coronavirus assay. Both alphacoronaviruses and betacoronaviruses were identified in samples from three species (<i>Miniopterus schreibersii</i>, <i>Rhinolophus ferrumequinum</i>, and <i>Rhinolophus hipposideros</i>). Strain sequences were related to coronaviruses detected in the last decade in northern Italy as well as in other countries bordering the Mediterranean basin, suggesting a widespread diffusion of these strains. This study supports the need for further monitoring efforts and early detection of circulating coronavirus genotypes, particularly for those which have been repeatedly emerging as zoonotic spillovers.
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spelling doaj-art-d595f1a35d784514b3fcef31d359d63a2025-08-20T03:47:54ZengMDPI AGPathogens2076-08172025-05-0114545710.3390/pathogens14050457Molecular Surveillance for Potential Zoonotic Pathogens in Troglophilus Bats: Detection and Molecular Characterization of Bat Coronaviruses in Southern ItalyFrancesco Mira0Francesca Gucciardi1Giorgia Schiró2Rosario Grasso3Maria Teresa Spena4Gábor Kemenesi5Claudia Vaiana6Davide Anzá7Laura Di Paola8Santina Di Bella9Annalisa Guercio10Giuseppa Purpari11Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyDipartimento di Scienze Biologiche, Geologiche e Ambientali, Università degli Studi di Catania, 95124 Catania, ItalyDipartimento di Scienze Biologiche, Geologiche e Ambientali, Università degli Studi di Catania, 95124 Catania, ItalyNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, H-7624 Pécs, HungaryIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyThe recent COVID-19 pandemic has renewed interest in bats, as they are natural hosts for numerous viruses, some of which have crossed species boundaries. Despite continued efforts in the past, the ecology of bat-related viruses in a significant part of national territories, such as Italy, remains largely unexplored. Herein, we describe the detection and molecular characterization of bat coronaviruses, identified during a viral survey on selected potential zoonotic pathogens (lyssavirus and coronaviruses) carried out in Sicily, southern Italy. A total number of 330 samples were collected from 149 bats in a period (November 2020–April 2023) overlapping the COVID-19 pandemic. All samples tested negative for lyssavirus and SARS-CoV-2, while 12 bats (8.05%) tested positive to a pan-coronavirus assay. Both alphacoronaviruses and betacoronaviruses were identified in samples from three species (<i>Miniopterus schreibersii</i>, <i>Rhinolophus ferrumequinum</i>, and <i>Rhinolophus hipposideros</i>). Strain sequences were related to coronaviruses detected in the last decade in northern Italy as well as in other countries bordering the Mediterranean basin, suggesting a widespread diffusion of these strains. This study supports the need for further monitoring efforts and early detection of circulating coronavirus genotypes, particularly for those which have been repeatedly emerging as zoonotic spillovers.https://www.mdpi.com/2076-0817/14/5/457batchiroptera<i>alphacoronavirus</i><i>betacoronavirus</i>SARS-CoV-2COVID-19
spellingShingle Francesco Mira
Francesca Gucciardi
Giorgia Schiró
Rosario Grasso
Maria Teresa Spena
Gábor Kemenesi
Claudia Vaiana
Davide Anzá
Laura Di Paola
Santina Di Bella
Annalisa Guercio
Giuseppa Purpari
Molecular Surveillance for Potential Zoonotic Pathogens in Troglophilus Bats: Detection and Molecular Characterization of Bat Coronaviruses in Southern Italy
Pathogens
bat
chiroptera
<i>alphacoronavirus</i>
<i>betacoronavirus</i>
SARS-CoV-2
COVID-19
title Molecular Surveillance for Potential Zoonotic Pathogens in Troglophilus Bats: Detection and Molecular Characterization of Bat Coronaviruses in Southern Italy
title_full Molecular Surveillance for Potential Zoonotic Pathogens in Troglophilus Bats: Detection and Molecular Characterization of Bat Coronaviruses in Southern Italy
title_fullStr Molecular Surveillance for Potential Zoonotic Pathogens in Troglophilus Bats: Detection and Molecular Characterization of Bat Coronaviruses in Southern Italy
title_full_unstemmed Molecular Surveillance for Potential Zoonotic Pathogens in Troglophilus Bats: Detection and Molecular Characterization of Bat Coronaviruses in Southern Italy
title_short Molecular Surveillance for Potential Zoonotic Pathogens in Troglophilus Bats: Detection and Molecular Characterization of Bat Coronaviruses in Southern Italy
title_sort molecular surveillance for potential zoonotic pathogens in troglophilus bats detection and molecular characterization of bat coronaviruses in southern italy
topic bat
chiroptera
<i>alphacoronavirus</i>
<i>betacoronavirus</i>
SARS-CoV-2
COVID-19
url https://www.mdpi.com/2076-0817/14/5/457
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