Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet
Exercise could afford multiple beneficial effects on obesity-related metabolic disorders. To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/5940732 |
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| author | Guangzeng Zhang Pengfei Yu Xiaomeng Liu |
| author_facet | Guangzeng Zhang Pengfei Yu Xiaomeng Liu |
| author_sort | Guangzeng Zhang |
| collection | DOAJ |
| description | Exercise could afford multiple beneficial effects on obesity-related metabolic disorders. To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training can significantly prevent HFD-induced weight gain and increase resting energy expenditure without affecting food intake. The insulin sensitivity was enhanced in the HFD + swim group than in the HFD + sedentary group. Moreover, swim training considerably decreased serum LPS content and downregulates epididymis white adipose tissue (eWAT) expression of the inflammatory mediator Tnf-α, Il-6, and Mcp-1. In summary, 13 weeks of swim training could reverse HFD-induced metabolic disorders including insulin resistance and inflammation. |
| format | Article |
| id | doaj-art-d5902a8ade224cdcad3b06bafde19f73 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d5902a8ade224cdcad3b06bafde19f732025-02-03T07:24:59ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/59407325940732Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat DietGuangzeng Zhang0Pengfei Yu1Xiaomeng Liu2Institute of Neuroscience and Translational Medicine, College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, Henan 466001, ChinaInstitute of Neuroscience and Translational Medicine, College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, Henan 466001, ChinaInstitute of Neuroscience and Translational Medicine, College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, Henan 466001, ChinaExercise could afford multiple beneficial effects on obesity-related metabolic disorders. To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training can significantly prevent HFD-induced weight gain and increase resting energy expenditure without affecting food intake. The insulin sensitivity was enhanced in the HFD + swim group than in the HFD + sedentary group. Moreover, swim training considerably decreased serum LPS content and downregulates epididymis white adipose tissue (eWAT) expression of the inflammatory mediator Tnf-α, Il-6, and Mcp-1. In summary, 13 weeks of swim training could reverse HFD-induced metabolic disorders including insulin resistance and inflammation.http://dx.doi.org/10.1155/2017/5940732 |
| spellingShingle | Guangzeng Zhang Pengfei Yu Xiaomeng Liu Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet International Journal of Endocrinology |
| title | Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet |
| title_full | Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet |
| title_fullStr | Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet |
| title_full_unstemmed | Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet |
| title_short | Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet |
| title_sort | swim training attenuates inflammation and improves insulin sensitivity in mice fed with a high fat diet |
| url | http://dx.doi.org/10.1155/2017/5940732 |
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