Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy
Introduction Muscle invasive bladder cancer during pregnancy is scarcely reported. Case presentation A 41‐year‐old ex‐smoker Asian female, managed with clean intermittent catheterization for 3 years due to neurogenic bladder caused by spinal cord disease, presented with gross hematuria at 10 weeks o...
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Wiley
2025-03-01
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| Series: | IJU Case Reports |
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| Online Access: | https://doi.org/10.1002/iju5.12827 |
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| author | Takeshi Sasaki Ikadai Ryota Akinobu Ishiyama Sho Takakura Momoko Kato Shunsuke Owa Taketomo Nishikawa Shinichiro Higashi Kouhei Nishikawa Takahiro Inoue |
| author_facet | Takeshi Sasaki Ikadai Ryota Akinobu Ishiyama Sho Takakura Momoko Kato Shunsuke Owa Taketomo Nishikawa Shinichiro Higashi Kouhei Nishikawa Takahiro Inoue |
| author_sort | Takeshi Sasaki |
| collection | DOAJ |
| description | Introduction Muscle invasive bladder cancer during pregnancy is scarcely reported. Case presentation A 41‐year‐old ex‐smoker Asian female, managed with clean intermittent catheterization for 3 years due to neurogenic bladder caused by spinal cord disease, presented with gross hematuria at 10 weeks of gestation. The patient was diagnosed with muscle invasive bladder cancer, cT3aN0M0. Maternal treatment was prioritized and gemcitabine plus cisplatin as neoadjuvant chemotherapy was started at 17 weeks of gestation. Cesarean section was performed at 32 weeks of gestation, followed by robot‐assisted radical cystectomy 3 weeks later. Histopathological examination revealed urothelial carcinoma, G3, ypT3b. Postoperative adjuvant nivolumab followed by enfortumab vedotin was not successful and the patient died 8 months after robot‐assisted radical cystectomy. Unfortunately, the premature infant with congenital heart disease died of necrotizing enterocolitis at 1‐month‐old. Conclusion Gemcitabine plus cisplatin chemotherapy in the patient with muscle invasive bladder cancer during pregnancy was safe but ultimately resulted in unfavorable outcomes in this case. |
| format | Article |
| id | doaj-art-d58f0ee9b1c6477eb9afa2987bc25cf5 |
| institution | OA Journals |
| issn | 2577-171X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj-art-d58f0ee9b1c6477eb9afa2987bc25cf52025-08-20T02:18:19ZengWileyIJU Case Reports2577-171X2025-03-018213814110.1002/iju5.12827Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancyTakeshi Sasaki0Ikadai Ryota1Akinobu Ishiyama2Sho Takakura3Momoko Kato4Shunsuke Owa5Taketomo Nishikawa6Shinichiro Higashi7Kouhei Nishikawa8Takahiro Inoue9Department of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanDepartment of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanDepartment of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanDepartment of Obstetrics and Gynecology Mie University School of Medicine Tsu Mie JapanDepartment of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanDepartment of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanDepartment of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanDepartment of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanDepartment of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanDepartment of Nephro‐Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu Mie JapanIntroduction Muscle invasive bladder cancer during pregnancy is scarcely reported. Case presentation A 41‐year‐old ex‐smoker Asian female, managed with clean intermittent catheterization for 3 years due to neurogenic bladder caused by spinal cord disease, presented with gross hematuria at 10 weeks of gestation. The patient was diagnosed with muscle invasive bladder cancer, cT3aN0M0. Maternal treatment was prioritized and gemcitabine plus cisplatin as neoadjuvant chemotherapy was started at 17 weeks of gestation. Cesarean section was performed at 32 weeks of gestation, followed by robot‐assisted radical cystectomy 3 weeks later. Histopathological examination revealed urothelial carcinoma, G3, ypT3b. Postoperative adjuvant nivolumab followed by enfortumab vedotin was not successful and the patient died 8 months after robot‐assisted radical cystectomy. Unfortunately, the premature infant with congenital heart disease died of necrotizing enterocolitis at 1‐month‐old. Conclusion Gemcitabine plus cisplatin chemotherapy in the patient with muscle invasive bladder cancer during pregnancy was safe but ultimately resulted in unfavorable outcomes in this case.https://doi.org/10.1002/iju5.12827cisplatingemcitabinemuscle‐invasive bladder cancerpregnancy |
| spellingShingle | Takeshi Sasaki Ikadai Ryota Akinobu Ishiyama Sho Takakura Momoko Kato Shunsuke Owa Taketomo Nishikawa Shinichiro Higashi Kouhei Nishikawa Takahiro Inoue Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy IJU Case Reports cisplatin gemcitabine muscle‐invasive bladder cancer pregnancy |
| title | Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy |
| title_full | Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy |
| title_fullStr | Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy |
| title_full_unstemmed | Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy |
| title_short | Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy |
| title_sort | muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy |
| topic | cisplatin gemcitabine muscle‐invasive bladder cancer pregnancy |
| url | https://doi.org/10.1002/iju5.12827 |
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