Gut associated metabolites and their roles in Clostridioides difficile pathogenesis
The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well established to generate a state that is susceptible to CDI. A variety of metabolites produced by the host and/or gut microbi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2094672 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850109026045526016 |
|---|---|
| author | Andrea Martinez Aguirre Joseph A. Sorg |
| author_facet | Andrea Martinez Aguirre Joseph A. Sorg |
| author_sort | Andrea Martinez Aguirre |
| collection | DOAJ |
| description | The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well established to generate a state that is susceptible to CDI. A variety of metabolites produced by the host and/or gut microbiota have been shown to interact with C. difficile. Certain bile acids promote/inhibit germination while other cholesterol-derived compounds and amino acids used in the Stickland metabolic pathway affect growth and CDI colonization. Short chain fatty acids maintain intestinal barrier integrity and a myriad of other metabolic compounds are used as nutritional sources or used by C. difficile to inhibit or outcompete other bacteria in the gut. As the move toward non-antibiotic CDI treatment takes place, a deeper understanding of interactions between C. difficile and the host’s gut microbiome and metabolites becomes more relevant. |
| format | Article |
| id | doaj-art-d58b995cb9054cf295f053546d1a36d1 |
| institution | OA Journals |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-d58b995cb9054cf295f053546d1a36d12025-08-20T02:38:11ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2094672Gut associated metabolites and their roles in Clostridioides difficile pathogenesisAndrea Martinez Aguirre0Joseph A. Sorg1Department of Biology, Texas A&M University, College Station, TX, USADepartment of Biology, Texas A&M University, College Station, TX, USAThe nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well established to generate a state that is susceptible to CDI. A variety of metabolites produced by the host and/or gut microbiota have been shown to interact with C. difficile. Certain bile acids promote/inhibit germination while other cholesterol-derived compounds and amino acids used in the Stickland metabolic pathway affect growth and CDI colonization. Short chain fatty acids maintain intestinal barrier integrity and a myriad of other metabolic compounds are used as nutritional sources or used by C. difficile to inhibit or outcompete other bacteria in the gut. As the move toward non-antibiotic CDI treatment takes place, a deeper understanding of interactions between C. difficile and the host’s gut microbiome and metabolites becomes more relevant.https://www.tandfonline.com/doi/10.1080/19490976.2022.2094672Clostridioides difficilegut metabolitesmicrobiomefecal microbial therapybile acidsStickland |
| spellingShingle | Andrea Martinez Aguirre Joseph A. Sorg Gut associated metabolites and their roles in Clostridioides difficile pathogenesis Gut Microbes Clostridioides difficile gut metabolites microbiome fecal microbial therapy bile acids Stickland |
| title | Gut associated metabolites and their roles in Clostridioides difficile pathogenesis |
| title_full | Gut associated metabolites and their roles in Clostridioides difficile pathogenesis |
| title_fullStr | Gut associated metabolites and their roles in Clostridioides difficile pathogenesis |
| title_full_unstemmed | Gut associated metabolites and their roles in Clostridioides difficile pathogenesis |
| title_short | Gut associated metabolites and their roles in Clostridioides difficile pathogenesis |
| title_sort | gut associated metabolites and their roles in clostridioides difficile pathogenesis |
| topic | Clostridioides difficile gut metabolites microbiome fecal microbial therapy bile acids Stickland |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2094672 |
| work_keys_str_mv | AT andreamartinezaguirre gutassociatedmetabolitesandtheirrolesinclostridioidesdifficilepathogenesis AT josephasorg gutassociatedmetabolitesandtheirrolesinclostridioidesdifficilepathogenesis |