Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat Knees
Polyvinyl Alcohol (PVA) hydrogel plugs were implanted in artificial osteochondral defects on the trochlear groove of rat knees. After 0, 3, 6, 12, and 24 weeks of followup, samples containing the implants were mechanically evaluated by creep indentation test, chemically, and histologically by optica...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2012/582685 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849695377595301888 |
|---|---|
| author | N. A. Batista A. A. Rodrigues V. P. Bavaresco J. R. L. Mariolani W. D. Belangero |
| author_facet | N. A. Batista A. A. Rodrigues V. P. Bavaresco J. R. L. Mariolani W. D. Belangero |
| author_sort | N. A. Batista |
| collection | DOAJ |
| description | Polyvinyl Alcohol (PVA) hydrogel plugs were implanted in artificial osteochondral defects on the trochlear groove of rat knees. After 0, 3, 6, 12, and 24 weeks of followup, samples containing the implants were mechanically evaluated by creep indentation test, chemically, and histologically by optical microscopy. The mechanical test pointed towards an increase of the implant creep modulus and the chemical analysis exhibited an increasing concentration of calcium and phosphorus within the implants over time. Optical microscopy showed no foreign body reaction and revealed formation, differentiation, and maintenance of new tissue at the defect/implant interface. The absence of implant wear indicated that the natural articular lubrication process was not disturbed by the implant. The performance of the irradiated and acetalized PVA was considered satisfactory for the proposed application. |
| format | Article |
| id | doaj-art-d58b6492fa3a4c15911e4d0fa9a499d2 |
| institution | DOAJ |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-d58b6492fa3a4c15911e4d0fa9a499d22025-08-20T03:19:47ZengWileyInternational Journal of Biomaterials1687-87871687-87952012-01-01201210.1155/2012/582685582685Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat KneesN. A. Batista0A. A. Rodrigues1V. P. Bavaresco2J. R. L. Mariolani3W. D. Belangero4Orthopaedic Biomaterials Laboratory, Faculty of Medical Sciences, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, no. 126, Cidade Universitária “Zeferino Vaz”, 13083-887 Campinas, SP, BrazilOrthopaedic Biomaterials Laboratory, Faculty of Medical Sciences, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, no. 126, Cidade Universitária “Zeferino Vaz”, 13083-887 Campinas, SP, BrazilDepartment of Plastic, Technical College Campinas (COTUCA), University of Campinas (UNICAMP), 13083-887 Campinas, SP, BrazilOrthopaedic Biomaterials Laboratory, Faculty of Medical Sciences, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, no. 126, Cidade Universitária “Zeferino Vaz”, 13083-887 Campinas, SP, BrazilOrthopaedic Biomaterials Laboratory, Faculty of Medical Sciences, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, no. 126, Cidade Universitária “Zeferino Vaz”, 13083-887 Campinas, SP, BrazilPolyvinyl Alcohol (PVA) hydrogel plugs were implanted in artificial osteochondral defects on the trochlear groove of rat knees. After 0, 3, 6, 12, and 24 weeks of followup, samples containing the implants were mechanically evaluated by creep indentation test, chemically, and histologically by optical microscopy. The mechanical test pointed towards an increase of the implant creep modulus and the chemical analysis exhibited an increasing concentration of calcium and phosphorus within the implants over time. Optical microscopy showed no foreign body reaction and revealed formation, differentiation, and maintenance of new tissue at the defect/implant interface. The absence of implant wear indicated that the natural articular lubrication process was not disturbed by the implant. The performance of the irradiated and acetalized PVA was considered satisfactory for the proposed application.http://dx.doi.org/10.1155/2012/582685 |
| spellingShingle | N. A. Batista A. A. Rodrigues V. P. Bavaresco J. R. L. Mariolani W. D. Belangero Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat Knees International Journal of Biomaterials |
| title | Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat Knees |
| title_full | Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat Knees |
| title_fullStr | Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat Knees |
| title_full_unstemmed | Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat Knees |
| title_short | Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat Knees |
| title_sort | polyvinyl alcohol hydrogel irradiated and acetalized for osteochondral defect repair mechanical chemical and histological evaluation after implantation in rat knees |
| url | http://dx.doi.org/10.1155/2012/582685 |
| work_keys_str_mv | AT nabatista polyvinylalcoholhydrogelirradiatedandacetalizedforosteochondraldefectrepairmechanicalchemicalandhistologicalevaluationafterimplantationinratknees AT aarodrigues polyvinylalcoholhydrogelirradiatedandacetalizedforosteochondraldefectrepairmechanicalchemicalandhistologicalevaluationafterimplantationinratknees AT vpbavaresco polyvinylalcoholhydrogelirradiatedandacetalizedforosteochondraldefectrepairmechanicalchemicalandhistologicalevaluationafterimplantationinratknees AT jrlmariolani polyvinylalcoholhydrogelirradiatedandacetalizedforosteochondraldefectrepairmechanicalchemicalandhistologicalevaluationafterimplantationinratknees AT wdbelangero polyvinylalcoholhydrogelirradiatedandacetalizedforosteochondraldefectrepairmechanicalchemicalandhistologicalevaluationafterimplantationinratknees |