Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics
We describe a primary hepatic neuroendocrine tumor of a 57-year-old Thai woman who presented in 2004 with a suspicious mass in the left hepatic lobe. She underwent left hepatectomy for the 10.5-cm mass, called intermediate grade neuroendocrine carcinoma of unknown origin, likely metastatic. The tumo...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2017/7931975 |
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| author | Mohd Elmugtaba Ibrahim Kerolos Abadeer Qihui (Jim) Zhai Aziza Nassar |
| author_facet | Mohd Elmugtaba Ibrahim Kerolos Abadeer Qihui (Jim) Zhai Aziza Nassar |
| author_sort | Mohd Elmugtaba Ibrahim |
| collection | DOAJ |
| description | We describe a primary hepatic neuroendocrine tumor of a 57-year-old Thai woman who presented in 2004 with a suspicious mass in the left hepatic lobe. She underwent left hepatectomy for the 10.5-cm mass, called intermediate grade neuroendocrine carcinoma of unknown origin, likely metastatic. The tumor recurred in 2007, then called recurrent primary hepatic neuroendocrine tumor (PHNET), and the patient underwent liver transplant. Because of similarity between the neuroendocrine tumor and a thyroid tumor—specifically, follicular-like characteristics—immunohistochemical stains for thyroglobulin, TTF1, and calcitonin were performed. However, all were negative. All imaging studies revealed no evidence of a primary lesion other than the liver mass. In 2008, the patient’s liver transplant failed because of ischemic cholangiopathy, and she underwent a second liver transplant. Seven years later, in 2015, she presented with metastatic neuroendocrine tumor of intermediate grade to the lung, consistent with metastatic PHNET. She underwent left upper-lobe wedge resection to remove the tumor. The patient is alive with no evidence of disease at 13 years after initial diagnosis. This rare variant of PHNET had thyroid-like morphologic characteristics but there is no evidence of primary thyroid tumor or thyroid markers in the primary and recurrent hepatic tumors and lung metastasis. |
| format | Article |
| id | doaj-art-d5844327747d4d3aadca67c455e0b2e7 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-d5844327747d4d3aadca67c455e0b2e72025-02-03T05:51:53ZengWileyCase Reports in Pathology2090-67812090-679X2017-01-01201710.1155/2017/79319757931975Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic CharacteristicsMohd Elmugtaba Ibrahim0Kerolos Abadeer1Qihui (Jim) Zhai2Aziza Nassar3Division of Neurology, Massey Cancer Center, VCU Medical Center, Richmond, VA, USADivision of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USAWe describe a primary hepatic neuroendocrine tumor of a 57-year-old Thai woman who presented in 2004 with a suspicious mass in the left hepatic lobe. She underwent left hepatectomy for the 10.5-cm mass, called intermediate grade neuroendocrine carcinoma of unknown origin, likely metastatic. The tumor recurred in 2007, then called recurrent primary hepatic neuroendocrine tumor (PHNET), and the patient underwent liver transplant. Because of similarity between the neuroendocrine tumor and a thyroid tumor—specifically, follicular-like characteristics—immunohistochemical stains for thyroglobulin, TTF1, and calcitonin were performed. However, all were negative. All imaging studies revealed no evidence of a primary lesion other than the liver mass. In 2008, the patient’s liver transplant failed because of ischemic cholangiopathy, and she underwent a second liver transplant. Seven years later, in 2015, she presented with metastatic neuroendocrine tumor of intermediate grade to the lung, consistent with metastatic PHNET. She underwent left upper-lobe wedge resection to remove the tumor. The patient is alive with no evidence of disease at 13 years after initial diagnosis. This rare variant of PHNET had thyroid-like morphologic characteristics but there is no evidence of primary thyroid tumor or thyroid markers in the primary and recurrent hepatic tumors and lung metastasis.http://dx.doi.org/10.1155/2017/7931975 |
| spellingShingle | Mohd Elmugtaba Ibrahim Kerolos Abadeer Qihui (Jim) Zhai Aziza Nassar Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics Case Reports in Pathology |
| title | Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics |
| title_full | Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics |
| title_fullStr | Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics |
| title_full_unstemmed | Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics |
| title_short | Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics |
| title_sort | primary hepatic neuroendocrine tumor with unusual thyroid follicular like morphologic characteristics |
| url | http://dx.doi.org/10.1155/2017/7931975 |
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