Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders
Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are hard to diagnose and treat early. They are characterised by progressive loss of neuronal function and structure leading to crippling cognitive, motor and psychiatric impairments. In recent years, nanobiosensor...
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Elsevier
2024-12-01
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| author | Thikra S. Dhahi Alaa Kamal Yousif Dafhalla A. Wesam Al-Mufti Mohamed Elshaikh Elobaid Tijjani Adam Subash C.B. Gopinath |
| author_facet | Thikra S. Dhahi Alaa Kamal Yousif Dafhalla A. Wesam Al-Mufti Mohamed Elshaikh Elobaid Tijjani Adam Subash C.B. Gopinath |
| author_sort | Thikra S. Dhahi |
| collection | DOAJ |
| description | Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are hard to diagnose and treat early. They are characterised by progressive loss of neuronal function and structure leading to crippling cognitive, motor and psychiatric impairments. In recent years, nanobiosensor engineering has emerged as a promising way to address the limitations of traditional diagnostic methods for neurodegenerative diseases. Nanobiosensors which combine nanotechnology and biosensing principles can detect disease specific biomarkers with high sensitivity and specificity to enable early and accurate diagnosis. One of the key advantages of nanobiosensors in diagnosing neurodegenerative diseases is their ability to detect and quantify specific proteins or molecules that are biomarkers for these conditions. For example, accumulation of amyloid beta peptides and hyperphosphorylation of tau protein are hallmarks of Alzheimer's disease. Nanobiosensors can be designed to selectively bind to these biomarkers providing rapid and non-invasive method for early disease detection. This enables more targeted and personalized treatment approaches. Furthermore, nanomaterials have shown potential in biosensing applications due to their unique physical, optical, and electrical properties. Their small size, large surface-to-volume ratio, and tunable properties enable them to interact with biological molecules in remarkable ways. One notable property is their ability to be functionalized with molecular beacons, reporter molecules, pacification layers, and targeting biomolecules, creating highly sensitive and specific biofunctional nanoprobes. This review aims to explore the promising role of nanobiosensor engineering in the early diagnosis and management of neurodegenerative disorders. |
| format | Article |
| id | doaj-art-d583f9bebb36471699bb965d175f4ee3 |
| institution | OA Journals |
| issn | 2590-1230 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Engineering |
| spelling | doaj-art-d583f9bebb36471699bb965d175f4ee32025-08-20T01:58:16ZengElsevierResults in Engineering2590-12302024-12-012410279010.1016/j.rineng.2024.102790Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disordersThikra S. Dhahi0Alaa Kamal Yousif Dafhalla1A. Wesam Al-Mufti2Mohamed Elshaikh Elobaid3Tijjani Adam4Subash C.B. Gopinath5Health and Medical Technicals College, Southern Technical University, Basrah, IraqDepartment of Computer Engineering, College of Computer Science and Engineering, University of Ha'il, KSA, Saudi ArabiaDepartment of Medical Physics, College of Science, Al-Karkh University of Science Al-Hadi University College, Baghdad, 10011, IraqFaculty of Electronic Engineering & Technology, Universiti Malaysia Perlis, 02600 Arau Perlis, MalaysiaFaculty of Electronic Engineering & Technology, Universiti Malaysia Perlis, 02600 Arau Perlis, Malaysia; Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia; Micro System Technology, Centre of Excellence (CoE), Universiti Malaysia Perlis (UniMAP), Perlis, Malaysia; Corresponding author. Faculty of Electronic Engineering & Technology, Universiti Malaysia Perlis, 02600 Arau Perlis, MalaysiaCenter for Global Health Research, Saveetha Medical College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai 602 105, Tamil Nadu, India; Department of Technical Sciences, Western Caspian University, Baku AZ 1075, AzerbaijanNeurodegenerative diseases like Alzheimer's disease and Parkinson's disease are hard to diagnose and treat early. They are characterised by progressive loss of neuronal function and structure leading to crippling cognitive, motor and psychiatric impairments. In recent years, nanobiosensor engineering has emerged as a promising way to address the limitations of traditional diagnostic methods for neurodegenerative diseases. Nanobiosensors which combine nanotechnology and biosensing principles can detect disease specific biomarkers with high sensitivity and specificity to enable early and accurate diagnosis. One of the key advantages of nanobiosensors in diagnosing neurodegenerative diseases is their ability to detect and quantify specific proteins or molecules that are biomarkers for these conditions. For example, accumulation of amyloid beta peptides and hyperphosphorylation of tau protein are hallmarks of Alzheimer's disease. Nanobiosensors can be designed to selectively bind to these biomarkers providing rapid and non-invasive method for early disease detection. This enables more targeted and personalized treatment approaches. Furthermore, nanomaterials have shown potential in biosensing applications due to their unique physical, optical, and electrical properties. Their small size, large surface-to-volume ratio, and tunable properties enable them to interact with biological molecules in remarkable ways. One notable property is their ability to be functionalized with molecular beacons, reporter molecules, pacification layers, and targeting biomolecules, creating highly sensitive and specific biofunctional nanoprobes. This review aims to explore the promising role of nanobiosensor engineering in the early diagnosis and management of neurodegenerative disorders.http://www.sciencedirect.com/science/article/pii/S2590123024010454Alzheimer's diseaseParkinson's diseaseDiagnosisNanobiosensor |
| spellingShingle | Thikra S. Dhahi Alaa Kamal Yousif Dafhalla A. Wesam Al-Mufti Mohamed Elshaikh Elobaid Tijjani Adam Subash C.B. Gopinath Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders Results in Engineering Alzheimer's disease Parkinson's disease Diagnosis Nanobiosensor |
| title | Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders |
| title_full | Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders |
| title_fullStr | Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders |
| title_full_unstemmed | Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders |
| title_short | Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders |
| title_sort | application of nanobiosensor engineering in the diagnosis of neurodegenerative disorders |
| topic | Alzheimer's disease Parkinson's disease Diagnosis Nanobiosensor |
| url | http://www.sciencedirect.com/science/article/pii/S2590123024010454 |
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