Mitoxantrone in combination with clofarabine (MITCL) in children, adolescents and young adults with relapsed/refractory acute leukaemia: final results of a phase I/II trialResearch in context

Mitoxantrone in combination with clofarabine (MITCL) in children, adolescents and young adults with relapsed/refractory acute leukaemia: final results of a phase I/II trialResearch in context

Summary: Background: Children with relapsed/refractory acute leukaemias have lower response rates to reinduction and decreased overall survival. Mitoxantrone and clofarabine both have proven efficacy in acute leukaemia. We present our final results utilising this novel reinduction platform as a bri...

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Bibliographic Details
Main Authors: Jessica Hochberg, Javier Oesterheld, Aliza Gardenswartz, Allyson Flower, Liana Klejmont, Jackie Basso, Qiuhu Shi, Lauren Harrison, Michael J. Borowitz, Michael R. Loken, Mitchell S. Cairo
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:EClinicalMedicine
Subjects:
Pediatrics
Leukaemia
Relapse
Reinduction
Bridging chemotherapy
Phase II
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025001439
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