MAIT and iNKT cells in tissue homeostasis and repair
Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) are innate-like T cells, which develop in the thymus through an original developmental program leading to the acquisition of effector memory and tissue targeting phenotypes. Consequently, they become tissue-resident and quic...
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Elsevier
2025-05-01
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| Series: | Immunobiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171298525000518 |
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| author | Rafael Almeida Paiva Marion Salou |
| author_facet | Rafael Almeida Paiva Marion Salou |
| author_sort | Rafael Almeida Paiva |
| collection | DOAJ |
| description | Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) are innate-like T cells, which develop in the thymus through an original developmental program leading to the acquisition of effector memory and tissue targeting phenotypes. Consequently, they become tissue-resident and quickly produce effector molecules both in a T cell receptor (TCR)-dependent manner after stimulation by activating antigens, and in a TCR-independent fashion in response to cytokines. The latter can trigger MAIT and iNKT cells similarly, potentially leading to redundant functions. MAIT and iNKT cells populate most peripheral tissues where they express a wide range of effector modules including immune type 1/2/17, regulatory and repair programs. This endows them with a plethora of functional properties from anti-infectious immunity to regulation of homeostatic processes and tissue repair. In this review, we summarize the current literature on how MAIT and iNKT cells maintain organ homeostasis and contribute to regeneration in vivo, mostly focused on adipose tissue, intestine, lung, liver and skin. Furthermore, we underline TCR- and/or cytokine-dependent mechanisms and potential redundant, non-redundant or even opposing functions. |
| format | Article |
| id | doaj-art-d580250e51dd4e33ad6222dbb05ad7f5 |
| institution | Kabale University |
| issn | 0171-2985 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Immunobiology |
| spelling | doaj-art-d580250e51dd4e33ad6222dbb05ad7f52025-08-20T03:24:34ZengElsevierImmunobiology0171-29852025-05-01230315291710.1016/j.imbio.2025.152917MAIT and iNKT cells in tissue homeostasis and repairRafael Almeida Paiva0Marion Salou1Institut Curie, PSL University, Inserm U932, Immunity and Cancer, 75005 Paris, FranceInstitut Curie, PSL University, Inserm U932, Immunity and Cancer, 75005 Paris, France; Corresponding author.Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) are innate-like T cells, which develop in the thymus through an original developmental program leading to the acquisition of effector memory and tissue targeting phenotypes. Consequently, they become tissue-resident and quickly produce effector molecules both in a T cell receptor (TCR)-dependent manner after stimulation by activating antigens, and in a TCR-independent fashion in response to cytokines. The latter can trigger MAIT and iNKT cells similarly, potentially leading to redundant functions. MAIT and iNKT cells populate most peripheral tissues where they express a wide range of effector modules including immune type 1/2/17, regulatory and repair programs. This endows them with a plethora of functional properties from anti-infectious immunity to regulation of homeostatic processes and tissue repair. In this review, we summarize the current literature on how MAIT and iNKT cells maintain organ homeostasis and contribute to regeneration in vivo, mostly focused on adipose tissue, intestine, lung, liver and skin. Furthermore, we underline TCR- and/or cytokine-dependent mechanisms and potential redundant, non-redundant or even opposing functions.http://www.sciencedirect.com/science/article/pii/S0171298525000518MAIT cellsiNKT cellsInnate-like T cellsTissue homeostasisTissue repairFibrosis |
| spellingShingle | Rafael Almeida Paiva Marion Salou MAIT and iNKT cells in tissue homeostasis and repair Immunobiology MAIT cells iNKT cells Innate-like T cells Tissue homeostasis Tissue repair Fibrosis |
| title | MAIT and iNKT cells in tissue homeostasis and repair |
| title_full | MAIT and iNKT cells in tissue homeostasis and repair |
| title_fullStr | MAIT and iNKT cells in tissue homeostasis and repair |
| title_full_unstemmed | MAIT and iNKT cells in tissue homeostasis and repair |
| title_short | MAIT and iNKT cells in tissue homeostasis and repair |
| title_sort | mait and inkt cells in tissue homeostasis and repair |
| topic | MAIT cells iNKT cells Innate-like T cells Tissue homeostasis Tissue repair Fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S0171298525000518 |
| work_keys_str_mv | AT rafaelalmeidapaiva maitandinktcellsintissuehomeostasisandrepair AT marionsalou maitandinktcellsintissuehomeostasisandrepair |