Anti-leukemia activity of the ethyl acetate extract from Gynostemma pentaphyllum (Thunb.) leaf against FLT3-overexpressing AML cells and its phytochemical characterization

Anti-leukemia activity of the ethyl acetate extract from Gynostemma pentaphyllum (Thunb.) leaf against FLT3-overexpressing AML cells and its phytochemical characterization

Abstract Background Gynostemma pentaphyllum (Thunb.), a traditional adaptogenic herb, is known for its bioactive components with potential anti-cancer properties. Acute myeloid leukemia (AML) progression is significantly influenced by Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) sign...

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Bibliographic Details
Main Authors: Khin Khin Gyi, Songyot Anuchapreeda, Nutjeera Intasai, Montree Tungjai, Siriporn Okonogi, Arihiro Iwasaki, Toyonobu Usuki, Singkome Tima
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Acute myeloid leukemia
Gynostemma pentaphyllum (Thunb.)
FLT3
WT1
Anti-leukemia
Dehydrovomifoliol
Online Access:https://doi.org/10.1186/s12906-025-04903-0
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